{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:42:34Z","timestamp":1788871354633,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005421","name":"Guilan University of Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005421","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This study determines the mean concentrations of free amino acids in stimulated and unstimulated whole saliva in healthy young adults. Standardised salivary amino acids as a substitute for their counterpart in blood, searched for the source of free amino acids in saliva, the probable correlation between particular amino acids with caries experience. Stimulated and unstimulated whole saliva were collected by the draining method in 31 dental students. Saliva was purified, and amino acids were separated by high\u2010performance liquid chromatography.\n                    <jats:styled-content style=\"fixed-case\">DMFT<\/jats:styled-content>\n                    scores were recorded, and the relation of amino acids to caries experience was explored by generalised linear model. Almost all amino acids had higher concentration in unstimulated whole saliva than in stimulated saliva. The normal range of amino acids (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    ) and their natural logarithm were defined. There was a significant relationship between caries experience and threonine (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00\u00b7008), citrulline (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00\u00b7023) and ornithine (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00\u00b7001) as a detrimental factor, whereas serin (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00\u00b7026), glutamine (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00\u00b7015) and phenylalanine (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00\u00b7014) had an inhibiting effect on caries. However, in comparison, salivary flow rate (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00\u00b7013) was a more preventive factor than amino acids. Amino acids in saliva contribute as a marker, instead of their counterpart in blood. Unstimulated saliva had higher concentration of amino acids. Amino acids have different impact on caries and may be one of underlying risk factors for caries experience.\n                  <\/jats:p>","DOI":"10.1111\/joor.12197","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T18:36:52Z","timestamp":1402943812000},"page":"759-767","source":"Crossref","is-referenced-by-count":16,"title":["Free amino acids in stimulated and unstimulated whole saliva: advantages or disadvantages"],"prefix":"10.1111","volume":"41","author":[{"given":"H.","family":"Masoudi Rad","sequence":"first","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rabiei","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine Faculty of Dentistry Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sobhani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sadegh Khanjani","sequence":"additional","affiliation":[{"name":"Guilan Reference Laboratory Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rahbar Taramsar","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine and Toxicology Faculty of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kazemnezhad Leili","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0353"},{"key":"e_1_2_9_3_1","first-page":"37","volume-title":"Salivary Diagnostic","author":"Wong DT","year":"2008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.06.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_9_6_1","first-page":"64","volume-title":"Dry Mouth. The Malevolent Symptom: A Clinical Guide","author":"Sreebny LM","year":"2010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.101.2618.230"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740021001"},{"key":"e_1_2_9_9_1","first-page":"179","volume-title":"Clinical Oral Science","author":"Harris M","year":"1998"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1999.3909644.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1026847"},{"key":"e_1_2_9_12_1","first-page":"185","article-title":"Salivary amino acids quantification using RP\u2010HPLC during normal menstrual cycle","volume":"3","author":"Alagendran S","year":"2009","journal-title":"Afr J Biochem Res"},{"key":"e_1_2_9_13_1","unstructured":"KNAUER.Handbook of amino acid analysis.Berlin:KNAUER ASI 22000."},{"key":"e_1_2_9_14_1","first-page":"117","volume-title":"Oral Biosciences","author":"Ferguson DB","year":"1999"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.08.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013651"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660023101"},{"key":"e_1_2_9_18_1","volume-title":"Biochemestry","author":"Berg JM","year":"2007"},{"key":"e_1_2_9_19_1","volume-title":"Medical Biochemistry","author":"Bhagavan NV","year":"2002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345480270040801"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345730520030301"},{"key":"e_1_2_9_22_1","first-page":"71","article-title":"Basic amino acid in the pathogenesis of caries","volume":"25","author":"Vrani\u0107 L","year":"1991","journal-title":"Acta Stomatol Croat"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.07.011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(84)90181-X"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(87)90032-X"},{"key":"e_1_2_9_26_1","first-page":"XIII","article-title":"Determination of amino acids in saliva using capillary electrophoresis with fluorimetric detection","volume":"69","author":"Pobozy E","year":"2007","journal-title":"J Biochem Biophys Methods"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoor.12197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoor.12197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.12197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:38:44Z","timestamp":1696235924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.12197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,16]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/joor.12197"],"URL":"https:\/\/doi.org\/10.1111\/joor.12197","archive":["Portico"],"relation":{},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,16]]}}}