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Lack of understanding of the underlying pathophysiological mechanisms of these pain conditions is one of the important reasons behind the problems in diagnostic and management. During the last two decades, neurophysiological, psychophysical, brain imaging and neuropathological methods have been systematically applied to study the trigeminal system in idiopathic oro\u2010facial pain. The findings in these studies have provided evidence for neuropathic involvement in the pathophysiology of <jats:styled-content style=\"fixed-case\">PIFP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content>. The present qualitative review is a joint effort of a group of oro\u2010facial pain specialists and researchers to appraise the literature on idiopathic oro\u2010facial pain with special focus on the currently available studies on their pathophysiological mechanisms. The implications of the findings of these studies for the clinical diagnosis and treatment of idiopathic oro\u2010facial pain conditions are discussed.<\/jats:p>","DOI":"10.1111\/joor.12256","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T06:12:39Z","timestamp":1418105559000},"page":"300-322","source":"Crossref","is-referenced-by-count":97,"title":["An update on pathophysiological mechanisms related to idiopathic oro\u2010facial pain conditions with implications for management"],"prefix":"10.1111","volume":"42","author":[{"given":"H.","family":"Forssell","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Institute of Dentistry University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology University of Turku and Turku University Hospital Turku 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