{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:25:29Z","timestamp":1778801129048,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to describe the current knowledge on the role of heritability in <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content> pain through a systematic review of the literature, including familiar aggregation studies and genetic association studies. For the systematic search of the literature, the <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>referred <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eporting <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>tems for <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystematic reviews and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eta\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nalyses) guidelines were followed. In total, 21 studies were included in the review, including five\u00a0familiar aggregation studies and 16 genetic association studies. From both familiar aggregation studies and genetic association studies, modest evidence for the role of heritability in <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content> pain was found. The literature mainly suggests genetic\u00a0contributions from candidate genes that encode proteins involved in the processing of painful stimuli from the serotonergic and catecholaminergic system. This systematic review shows that the evidence for the role of heritability in the development of <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content> pain is cumulating.<\/jats:p>","DOI":"10.1111\/joor.12263","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:13:12Z","timestamp":1418987592000},"page":"386-399","source":"Crossref","is-referenced-by-count":26,"title":["TMD pain is partly heritable. A systematic review of family studies and genetic association studies"],"prefix":"10.1111","volume":"42","author":[{"given":"C. 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