{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:15Z","timestamp":1787015655927,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T00:00:00Z","timestamp":1419552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81271171"],"award-info":[{"award-number":["81271171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>\n \n Although psychosocial factors and malocclusion are regarded as potential causes of temporomandibular disorders (\n TMD<\/jats:styled-content>\n ), the underlying pathogenesis is poorly understood. Recent studies suggest that substance P (\n SP<\/jats:styled-content>\n ), which has been associated with both psychosocial factors and malocclusion, and histamine, whose release can be induced by\n SP<\/jats:styled-content>\n , may be implicated in the pathogenetic process. This study was designed to measure the concentration of histamine and\n SP<\/jats:styled-content>\n in synovial fluid (\n SF<\/jats:styled-content>\n ) of both 38 patients with\n TMD<\/jats:styled-content>\n and 11 healthy controls, and analyse the correlation between histamine and\n SP<\/jats:styled-content>\n . Patients with\n TMD<\/jats:styled-content>\n were divided into three subgroups: displaced disc with reduction (\n DDR<\/jats:styled-content>\n ), displaced disc without reduction (\n DDNR<\/jats:styled-content>\n ) and osteoarthritis (\n OA<\/jats:styled-content>\n ), with 10, 13, 15 subjects in every subgroup, respectively. After collecting\n SF<\/jats:styled-content>\n samples, histamine and\n SP<\/jats:styled-content>\n levels were measured by enzyme\u2010linked immunosorbent assay analysis (\n ELISA<\/jats:styled-content>\n ) and calibrated by bicinchoninic acid (\n BCA<\/jats:styled-content>\n )\u2010quantified protein level in the samples. The results suggest that\n OA<\/jats:styled-content>\n group presented a significantly higher level of both histamine and\n SP<\/jats:styled-content>\n than\n DDNR<\/jats:styled-content>\n ,\n DDR<\/jats:styled-content>\n and healthy control groups. Histamine or\n SP<\/jats:styled-content>\n in\n DDR<\/jats:styled-content>\n and\n DDNR<\/jats:styled-content>\n groups tend to be higher than control group, but no significance was found. Painful\n TMJ<\/jats:styled-content>\n s show higher histamine and\n SP<\/jats:styled-content>\n than painless\n TMJ<\/jats:styled-content>\n s. Correlation analysis reveals a significant correlation between histamine and\n SP<\/jats:styled-content>\n concentrations. Collectively, this study showed the changes of histamine and\n SP<\/jats:styled-content>\n in the\n SF<\/jats:styled-content>\n from different stages of\n TMD<\/jats:styled-content>\n and found a significant correlation between the two substances, suggesting their potential implication in the pathogenesis of\n TMD<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/joor.12265","type":"journal-article","created":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T05:35:22Z","timestamp":1419572122000},"page":"363-369","source":"Crossref","is-referenced-by-count":15,"title":["Histamine and substance\n P<\/scp>\n in synovial fluid of patients with temporomandibular disorders"],"prefix":"10.1111","volume":"42","author":[{"given":"W.","family":"Li","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School & Hospital of Stomatology Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jiang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School & Hospital of Stomatology Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School & Hospital of Stomatology Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Wuhan University Wuhan Hubei 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