{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:14:57Z","timestamp":1790802897936,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The aim of the study was to compare the effectiveness of two single\u2010session protocols, either adopting high\u2010 (protocol A) or medium\u2010molecular weight hyaluronic acid (protocol B), with the reference five\u2010session protocol of temporomandibular joint (TMJ) lavage plus viscosupplementation (protocol C) in the management of chronic TMJ degenerative disorders. A randomized clinical trial (RCT) with ten participants per treatment group was designed, with multiple observation points, ending at 6\u00a0months after treatment. Pain levels on a 10\u2010point VAS scale were selected as the primary outcome variable to rate treatment effectiveness, along with a number of secondary outcome parameters. Findings showed that Group C patients had the highest decrease in pain levels. Nonparametric permutation analyses revealed that the global effect of treatment was significantly different between the three protocols (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b7024). Pairwise comparisons showed that the differences of treatment effect between the two single\u2010session interventions were negligible (global\n                    <jats:italic>P<\/jats:italic>\n                    \u2010value\u00a0=\u00a00\u00b793). On the contrary, the five\u2010session protocol was significantly superior to both single\u2010session protocols (global\n                    <jats:italic>P<\/jats:italic>\n                    \u2010values ranging from 0\u00b7003 to 0\u00b7012). In conclusion, in a population of age\u2010, sex\u2010, and psychosocial aspects\u2010matched study groups, the standard of reference five\u2010session protocol proved to be superior at 6\u00a0months as far as the decrease in pain levels was concerned, whilst there were no differences between the two single\u2010session interventions. The absence of differences in treatment effect as for some other secondary clinical outcome variables may suggest that there is further space for future investigations attempting to reduce the number of multiple interventions for TMJ viscosupplementation.\n                  <\/jats:p>","DOI":"10.1111\/joor.12282","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T23:36:51Z","timestamp":1424389011000},"page":"521-528","source":"Crossref","is-referenced-by-count":54,"title":["Single\u2010 or multiple\u2010session viscosupplementation protocols for temporomandibular joint degenerative disorders: a randomized clinical trial"],"prefix":"10.1111","volume":"42","author":[{"given":"L.","family":"Guarda\u2010Nardini","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery Temporomandibular Disorders Clinic University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery Temporomandibular Disorders Clinic University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Arboretti","sequence":"additional","affiliation":[{"name":"Department of Land Use and AgriForestal Systems University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bonnini","sequence":"additional","affiliation":[{"name":"Department of Economics and Management University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Stellini","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Padova Padova 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