{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:28:33Z","timestamp":1761823713147,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31271548"],"award-info":[{"award-number":["31271548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Temporomandibular joint osteoarthritis (<jats:styled-content style=\"fixed-case\">TMJOA<\/jats:styled-content>) is a complex disease and has a strong genetic component in its pathogenesis. Experimental evidence suggests the involvement of biological pathway in the disease. This case\u2013control study was designed to investigate whether five common single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in <jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>5, <jats:styled-content style=\"fixed-case\">SMAD<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b21 and <jats:styled-content style=\"fixed-case\">CHST<\/jats:styled-content>11, respectively, are associated with <jats:styled-content style=\"fixed-case\">TMJOA<\/jats:styled-content> in female Han Chinese patients. A total of 240 participants were evaluated comprising 114 female patients diagnosed with <jats:styled-content style=\"fixed-case\">TMJOA<\/jats:styled-content> based on Research Diagnostic Criteria for Temporomandibular Disorders and 126 healthy female controls. The <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of the five genes in the genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> were examined by sequencing, and their allelic, genotypic and carriage rate frequency distributions, as well as the triple combination of the risk genotypes, were analysed using the logistic regression model. The <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>5 or <jats:styled-content style=\"fixed-case\">SMAD<\/jats:styled-content>3 showed significant association with <jats:styled-content style=\"fixed-case\">TMJOA<\/jats:styled-content>, a relatively weak association was observed in <jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>2. In the triple combinational analysis, the risk of <jats:styled-content style=\"fixed-case\">TMJOA<\/jats:styled-content> grew 5\u00b709 times in the patients with five or six risk alleles (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701). This is the first study to evaluate the association of <jats:styled-content style=\"fixed-case\">GDF<\/jats:styled-content>5, <jats:styled-content style=\"fixed-case\">SMAD<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b21 and <jats:styled-content style=\"fixed-case\">CHST<\/jats:styled-content>11 with <jats:styled-content style=\"fixed-case\">TMJOA<\/jats:styled-content> in female Han Chinese. Our study suggests that the <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of genes related to <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b2 family might contribute to the risk of <jats:styled-content style=\"fixed-case\">TMJOA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/joor.12286","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T08:38:49Z","timestamp":1425976729000},"page":"529-536","source":"Crossref","is-referenced-by-count":18,"title":["Association of <scp>GDF<\/scp>5, <scp>SMAD<\/scp>3 and <scp>RUNX<\/scp>2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese"],"prefix":"10.1111","volume":"42","author":[{"given":"J.\u2010L.","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010H.","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010H.","family":"Gan","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Joint Disorder and Orofacial Pain Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010Y.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Peking University School of Basic Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.\u2010C.","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Temporomandibular Joint Disorder and Orofacial Pain Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.121"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357209019791"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2007.01.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740110401"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/AJP.0b013e318287a358","article-title":"Catechol\u2010O\u2010methyltransferase COMT gene polymorphisms as risk factor in temporomandibular disorders patients from Southern Italy","volume":"30","author":"Michelotti A","year":"2014","journal-title":"Clin J Pain"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.02.023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00803.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2006.12.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.199"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.10023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq245"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.6.1305"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-315"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-18"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.610610.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/2005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn038"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27530"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2593-z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60681-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207676"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01948"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2662-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2009.02008.x"},{"key":"e_1_2_7_26_1","first-page":"315","article-title":"Temporomandibular disorders among schizophrenic patients. A case\u2010control study","volume":"10","author":"Velasco\u2010Ortega E","year":"2005","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.05.006"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2741\/s266"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_7_30_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin SF","year":"1992","journal-title":"J Craniomandib Disord"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003557"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr253"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.101"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1990"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.02.931"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.08.008"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090167"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.81"},{"key":"e_1_2_7_39_1","first-page":"279","article-title":"Transforming growth factor\u2010beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint","volume":"71","author":"Beuningen HM","year":"1994","journal-title":"Lab Invest"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00022-2"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)46918-9"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302048200"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0832-8"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.11.004"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(03)00088-8"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34566"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoor.12286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoor.12286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.12286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T11:52:47Z","timestamp":1696161167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.12286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/joor.12286"],"URL":"https:\/\/doi.org\/10.1111\/joor.12286","archive":["Portico"],"relation":{},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"type":"print","value":"0305-182X"},{"type":"electronic","value":"1365-2842"}],"subject":[],"published":{"date-parts":[[2015,3,10]]}}}