{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:10:05Z","timestamp":1792606205233,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81470726"],"award-info":[{"award-number":["81470726"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) displays a high remodelling capability. The current purpose was to investigate the differences between mandibular condylar remodelling responses of growing mice to installation and removal of unilateral anterior crossbite (<jats:styled-content style=\"fixed-case\">UAC<\/jats:styled-content>) prosthesis. Twenty\u2010four mice were divided into one mock control group and two <jats:styled-content style=\"fixed-case\">UAC<\/jats:styled-content> groups. Unilateral anterior crossbite was created by installing a pair of prosthesis to left\u2010side maxillary and mandibular incisors. Unilateral anterior crossbite was removed in removal group at 3\u00a0weeks but remained in <jats:styled-content style=\"fixed-case\">UAC <\/jats:styled-content> group. Temporomandibular joints were sampled at 7\u00a0weeks. Changes in condylar cartilage and subchondral bone were assessed by histology and <jats:italic>in\u00a0vivo<\/jats:italic> micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>. Real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and immunohistochemistry were performed to evaluate expression changes in <jats:styled-content style=\"fixed-case\">ADAMTS<\/jats:styled-content>\u20105, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>, OPG and RANKL. Statistical analysis was performed at <jats:italic>\u03b1\u00a0<\/jats:italic>=\u00a00\u00b705. Temporomandibular joint cartilage degradation was induced by <jats:styled-content style=\"fixed-case\">UAC<\/jats:styled-content> as previously reported but was reversed by removal of <jats:styled-content style=\"fixed-case\">UAC<\/jats:styled-content>. The dropped cartilage thickness, chondrocyte number and collagen <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010positive area, the increased expression levels of <jats:italic>Adamts\u20105<\/jats:italic>,<jats:italic> Mmp3<\/jats:italic>,<jats:italic> 9<\/jats:italic>,<jats:italic> 13<\/jats:italic>,<jats:italic> Tnf\u2010\u03b1<\/jats:italic> and <jats:italic>Il\u20101\u03b2<\/jats:italic> in cartilage, the decreased ratio of <jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">RANKL<\/jats:styled-content> in both condylar cartilage and subchondral bone, the loss of <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> subchondral bone and the increase in the <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\u2010positive cells in subchondral bone were all reversed in the removal group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). The growing mouse <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> condyle displays a high remodelling capability which can be degenerative and rehabilitative, respectively, in response to placement and thereafter removal of the aberrant prosthesis. Eliminating aberrant prosthesis is helpful to promote the degraded condyle to recover.<\/jats:p>","DOI":"10.1111\/joor.12304","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T04:49:11Z","timestamp":1430542151000},"page":"685-692","source":"Crossref","is-referenced-by-count":24,"title":["Installing and thereafter removing an aberrant prosthesis elicited opposite remodelling responses in growing mouse temporomandibular joints"],"prefix":"10.1111","volume":"42","author":[{"given":"H.\u2010Y.","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Anatomy and Physiology and TMD School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010D.","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Anatomy and Physiology and TMD School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010X.","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Anatomy and Physiology and TMD School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Anatomy and Physiology and TMD School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010F.","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Anatomy and Physiology and TMD School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010H.","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Anatomy and Physiology and TMD School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010Q.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology Department of Oral Anatomy and Physiology and TMD School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"168","article-title":"Degenerative disease of the\u00a0temporomandibular joint","volume":"9","author":"Kamelchuk LS","year":"1995","journal-title":"J Orofac 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