{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:19:34Z","timestamp":1791847174405,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,7]],"date-time":"2015-06-07T00:00:00Z","timestamp":1433635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Summary<\/jats:title>\n \n There is a lack of knowledge about the effectiveness of manual therapy (\n MT<\/jats:styled-content>\n ) on subjects with temporomandibular disorders (\n TMD<\/jats:styled-content>\n ). The aim of this systematic review is to synthetise evidence regarding the isolated effect of\n MT<\/jats:styled-content>\n in improving maximum mouth opening (\n MMO<\/jats:styled-content>\n ) and pain in subjects with signs and symptoms of\n TMD<\/jats:styled-content>\n .\n MEDLINE<\/jats:styled-content>\n \u00ae<\/jats:sup>\n , Cochrane, Web of Science, Sci\n ELO<\/jats:styled-content>\n and\n EMBASE<\/jats:styled-content>\n \u2122<\/jats:sup>\n electronic databases were consulted, searching for randomised controlled trials applying\n MT<\/jats:styled-content>\n for\n TMD<\/jats:styled-content>\n compared to other intervention, no intervention or placebo. Two authors independently extracted data,\n PED<\/jats:styled-content>\n ro scale was used to assess risk of bias, and\n GRADE<\/jats:styled-content>\n (Grading of Recommendations Assessment, Development and Evaluation) was applied to synthetise overall quality of the body of evidence. Treatment effect size was calculated for pain,\n MMO<\/jats:styled-content>\n and pressure pain threshold (\n PPT<\/jats:styled-content>\n ). Eight trials were included, seven of high methodological quality. Myofascial release and massage techniques applied on the masticatory muscles are more effective than control (low to moderate evidence) but as effective as toxin botulinum injections (moderate evidence). Upper cervical spine thrust manipulation or mobilisation techniques are more effective than control (low to high evidence), while thoracic manipulations are not. There is moderate\u2010to\u2010high evidence that\n MT<\/jats:styled-content>\n techniques protocols are effective. The methodological heterogeneity across trials protocols frequently contributed to decrease quality of evidence. In conclusion, there is widely varying evidence that\n MT<\/jats:styled-content>\n improves pain,\n MMO<\/jats:styled-content>\n and\n PPT<\/jats:styled-content>\n in subjects with\n TMD<\/jats:styled-content>\n signs and symptoms, depending on the technique. Further studies should consider using standardised evaluations and better study designs to strengthen clinical relevance.\n <\/jats:p>","DOI":"10.1111\/joor.12321","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T21:26:21Z","timestamp":1433971581000},"page":"847-861","source":"Crossref","is-referenced-by-count":156,"title":["Manual therapy for the management of pain and limited range of motion in subjects with signs and symptoms of temporomandibular disorder: a systematic review of randomised controlled trials"],"prefix":"10.1111","volume":"42","author":[{"given":"L. 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