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The purpose of the study was to review the status of biobehavioural research \u2013 both quantitative and qualitative \u2013 related to oro\u2010facial pain (<jats:styled-content style=\"fixed-case\">OFP<\/jats:styled-content>) with respect to the aetiology, pathophysiology, diagnosis and management of <jats:styled-content style=\"fixed-case\">OFP<\/jats:styled-content> conditions, and how this information can optimally be used for developing a structured <jats:styled-content style=\"fixed-case\">OFP<\/jats:styled-content> classification system for research. In particular, we address representation of psychosocial entities in classification systems, use of qualitative research to identify and understand the full scope of psychosocial entities and their interaction, and the usage of classification system for guiding treatment. 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