{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:53:49Z","timestamp":1774500829329,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T00:00:00Z","timestamp":1457222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to investigate the bone resorption effect of the mediators delivered in joint cavity of patients with mandibular condyle fractures by detecting osteoclast markers using cellular biochemistry methods, and by analysing bone resorption activities via inducing osteoclast differentiation of the infiltrated cells from arthrocentesis. Sixteen joints in 10 patients with mandibular condyle fractures were evaluated. The control group consisted of synovial fluid (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>) samples from seven joints of four volunteers who had no clinical signs or symptoms involving the temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) or disc displacement. We collected <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> cells from all patients during therapeutic arthrocentesis. The infiltrating cells from <jats:styled-content style=\"fixed-case\">TMJ SF<\/jats:styled-content> were cultured, differentiated into tartrate\u2010resistant acid phosphatase (<jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>)\u2010positive osteoclast\u2010like cells and examined bone resorption activities. We also investigated factors related to osteoclast induction of <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>, using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> procedures. Osteoclast\u2010like cells were induced from the <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> cells obtained from all patients with condylar fractures. These multinucleated giant cells were positive for <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content> and actin, and had the ability to absorb dentin slices. The levels of macrophage colony\u2010stimulating factor (M\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>), prostaglandin E2 (<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2), soluble form of receptor activator of nuclear factor kappa\u2010B ligand (<jats:styled-content style=\"fixed-case\">sRANKL<\/jats:styled-content>) and osteoprotegerin (<jats:styled-content style=\"fixed-case\">OPG<\/jats:styled-content>), in <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> samples from the patients, were significantly higher than in the controls. These findings indicate that bone resorption activities in <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> from patients with mandibular condyle fractures were upregulated and may participate in the pathogenesis and wound healing.<\/jats:p>","DOI":"10.1111\/joor.12388","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T11:31:37Z","timestamp":1457263897000},"page":"333-339","source":"Crossref","is-referenced-by-count":4,"title":["Facilitation of bone resorption activities in synovial lavage fluid patients with mandibular condyle fractures"],"prefix":"10.1111","volume":"43","author":[{"given":"H.","family":"Takano","sequence":"first","affiliation":[{"name":"Department of Dentistry and Oral Surgery Akita University Graduate School of Medicine Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Maxillofacial Surgery Department 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