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Notwithstanding the significant progress in our knowledge spanning from molecules to chair, there may also be limitations in our ability to integrate and interpret the tremendous amount of new data and information, in particular in terms of the clinical implications and overriding conceptual models for oro\u2010facial pain. The aim of the present narrative review is to briefly summarise some of the current thoughts on oro\u2010facial pain mechanisms and recent attempts to identify biomarkers and risk factors leading to the proposal of a new risk assessment diagram for oro\u2010facial pain (<jats:styled-content style=\"fixed-case\">RADOP<\/jats:styled-content>) and a provocative new concept based on stochastic variation between multiple risk factors. Finally, the implications for novel management strategies will briefly be discussed.<\/jats:p>","DOI":"10.1111\/joor.12447","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T03:26:21Z","timestamp":1475724381000},"page":"977-989","source":"Crossref","is-referenced-by-count":42,"title":["Assessment of risk factors for oro\u2010facial pain and recent developments in classification: implications for management"],"prefix":"10.1111","volume":"43","author":[{"given":"P.","family":"Svensson","sequence":"first","affiliation":[{"name":"Section of Orofacial Pain and Jaw Function Institute of Odontology and Oral Health Aarhus University Aarhus Denmark"},{"name":"Department of Dental Medicine Karolinska Institute Huddinge Sweden"},{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Aarhus University Aarhus 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