{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:30:45Z","timestamp":1784079045949,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008364","name":"Tandl\u00e6geforeningen","doi-asserted-by":"publisher","award":["21318418"],"award-info":[{"award-number":["21318418"]}],"id":[{"id":"10.13039\/100008364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>) in long\u2010term treatment with a mandibular advancement device (<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>) to increase the upper airway space may develop changes in the temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) and the oro\u2010facial function due to the protruded jaw position during sleep. The aim was to investigate the influence of long\u2010term <jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content> treatment on the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s, oro\u2010facial function and occlusion. This prospective study included 30 men and 13 women (median age 54) with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> [Apnoea\u2013Hypopnoea Index (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>): 7\u201357]. They were examined with the <jats:italic>Nordic Orofacial Test Screening<\/jats:italic> (<jats:styled-content style=\"fixed-case\">NOT<\/jats:styled-content>\u2010S), the <jats:italic>Research Diagnostic Criteria for Temporomandibular Disorders<\/jats:italic> (<jats:styled-content style=\"fixed-case\">RDC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>) and cone beam computed tomography (<jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>) of the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s. The examination was performed before <jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content> treatment (T0), and 3\u20136 months (T1, no <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content>), 1 year (T2) and 3 years (T3) after treatment start. The results were analysed as <jats:italic>long term<\/jats:italic> (T0\u2013T3, <jats:italic>n<\/jats:italic> = 14) and <jats:italic>short term<\/jats:italic> (T0\u2013T2, <jats:italic>n<\/jats:italic> = 24) by <jats:italic>t<\/jats:italic>\u2010test, Fisher's exact test and <jats:sc>anova<\/jats:sc>. Both long\u2010 and short\u2010term analyses revealed a reduction in <jats:italic><jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content><\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 0\u00b7002). Significant long term were increased scores in the <jats:italic><jats:styled-content style=\"fixed-case\">NOT<\/jats:styled-content>\u2010S Interview<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 0\u00b7045), reduced <jats:italic>vertical overbite<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 0\u00b7031) and increased jaw <jats:italic>protrusive movement<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 0\u00b7027). <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> changes were found as joint sounds in terms of <jats:italic>reciprocal clicking<\/jats:italic> and <jats:italic>crepitus,<\/jats:italic> short term as a decrease and subsequent recurrence (<jats:italic>P<\/jats:italic> &lt; 0\u00b7053; <jats:italic>P<\/jats:italic> &lt; 0\u00b7037). No significant radiological changes were found. In conclusion, <jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content> treatment is beneficial to some <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> patients, but might induce changes in the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s, the oro\u2010facial function and the occlusion. However, these changes seemed to be less harmful than previously reported with careful adaptation, control and follow\u2010ups.<\/jats:p>","DOI":"10.1111\/joor.12485","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T18:31:20Z","timestamp":1484677880000},"page":"354-362","source":"Crossref","is-referenced-by-count":39,"title":["Long\u2010term side effects on the temporomandibular joints and oro\u2010facial function in patients with obstructive sleep apnoea treated with a mandibular advancement device"],"prefix":"10.1111","volume":"44","author":[{"given":"S. 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