{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:01:49Z","timestamp":1779260509198,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Children who suffer from cerebral palsy (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) often present comorbidities in the form of oro\u2010facial dysfunctions. Studies in animals have contributed to elaborate potential therapies aimed at minimising the chronic disability of the syndrome. To systematically review the scientific literature regarding the possible effects that experimental models of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> can have on oro\u2010facial functions. Two independent authors conducted a systematic review in the electronic databases Medline, Scopus, <jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>, Web of Science and Lilacs, using Mesh and Decs terms in animal models. The motor and sensory parameters of sucking, chewing and swallowing were considered as primary outcomes; reactivity odour, controlled salivation, postural control, head mobility during feeding and the animal's ability to acquire food were secondary outcomes. Ten studies were included in the present review. Most studies used rabbits as experimental models of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, which was induced by either hypoxia\u2010ischemia, inflammation or intraventricular haemorrhage. Oro\u2010facial functions were altered in all experimental models of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. However, we found more modifications in hypoxia\u2010ischemia models overall. On the other hand, the model of inflammation was more effective to reproduce higher damage for coordinating sucking and swallowing. All of the <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> experimental models that were assessed modified the oral functions in different animal species. However, further studies should be conducted in order to clarify the mechanisms underlying oro\u2010facial damage in order to optimise treatment strategies for children who suffer from <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/joor.12489","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T14:16:41Z","timestamp":1486217801000},"page":"251-260","source":"Crossref","is-referenced-by-count":12,"title":["Oro\u2010facial functions in experimental models of cerebral palsy: a systematic review"],"prefix":"10.1111","volume":"44","author":[{"given":"D. C.","family":"Lacerda","sequence":"first","affiliation":[{"name":"Post Graduate Program in Nutrition Federal University of Pernambuco UFPE Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-0866","authenticated-orcid":false,"given":"K. 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