{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:48:48Z","timestamp":1791841728569,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001722","name":"Koninklijke Nederlandse Akademie van Wetenschappen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obstructive sleep apnoea syndrome (<jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content>) is associated with several sleep disorders and sleep\u2010related problems. Therefore, the aim of this study was to compare the effects of a mandibular advancement device (<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>) with those of nasal continuous positive airway pressure (<jats:styled-content style=\"fixed-case\">nCPAP<\/jats:styled-content>) on self\u2010reported symptoms of common sleep disorders and sleep\u2010related problems in mild and moderate<jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content>patients. In this randomised placebo\u2010controlled trial, sixty\u2010four<jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content>patients (52\u00b70\u00a0\u00b1\u00a09\u00b76\u00a0years) were randomly assigned to an<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">nCPAP<\/jats:styled-content>or an intra\u2010oral placebo appliance in a parallel design. All participants filled out the validated Dutch Sleep Disorders Questionnaire (<jats:styled-content style=\"fixed-case\">SDQ<\/jats:styled-content>) twice: one before treatment and one after six months of treatment. With 88 questions, thirteen scales were constructed, representing common sleep disorders and sleep\u2010related problems. Linear mixed model analyses were performed to study differences between the groups for the different<jats:styled-content style=\"fixed-case\">SDQ<\/jats:styled-content>scales over time. The<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>group showed significant improvements over time in symptoms corresponding with \u2018insomnia\u2019, \u2018excessive daytime sleepiness\u2019, \u2018psychiatric sleep disorder\u2019, \u2018periodic limb movements\u2019, \u2018sleep apnoea\u2019, \u2018sleep paralysis\u2019, \u2018daytime dysfunction\u2019, \u2018hypnagogic hallucinations\/dreaming\u2019, \u2018restless sleep\u2019, \u2018negative conditioning\u2019 and \u2018automatic behaviour\u2019 (range of<jats:italic>P<\/jats:italic>values: 0\u00b7000\u20130\u00b7014). These improvements in symptoms were, however, not significantly different from the improvements in symptoms observed in the<jats:styled-content style=\"fixed-case\">nCPAP<\/jats:styled-content>and placebo groups (range of<jats:italic>P<\/jats:italic>values: 0\u00b7090\u20130\u00b7897). It can be concluded that there is no significant difference between<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">nCPAP<\/jats:styled-content>in their positive effects on self\u2010reported symptoms of common sleep disorders and sleep\u2010related problems in mild and moderate<jats:styled-content style=\"fixed-case\">OSAS<\/jats:styled-content>patients. These beneficial effects may be a result of placebo effects.<\/jats:p>","DOI":"10.1111\/joor.12505","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:53:16Z","timestamp":1489168396000},"page":"452-460","source":"Crossref","is-referenced-by-count":24,"title":["Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnoea syndrome: a randomised, placebo\u2010controlled trial on self\u2010reported symptoms of common sleep disorders and sleep\u2010related problems"],"prefix":"10.1111","volume":"44","author":[{"given":"M.","family":"Nikolopoulou","sequence":"first","affiliation":[{"name":"Department of Oral Kinesiology Academic Centre for Dentistry Amsterdam (ACTA) MOVE Research Institute Amsterdam University of Amsterdam and VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Byraki","sequence":"additional","affiliation":[{"name":"Department of Oral Kinesiology Academic Centre for Dentistry Amsterdam (ACTA) MOVE Research Institute Amsterdam University of Amsterdam and VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ahlberg","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W.","family":"Heymans","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics VU University Medical Center Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L.","family":"Hamburger","sequence":"additional","affiliation":[{"name":"Amsterdam Sleep Centre Boerhaave Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"De Lange","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Academic Medical Centre of the University of Amsterdam and Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lobbezoo","sequence":"additional","affiliation":[{"name":"Department of Oral Kinesiology Academic Centre for Dentistry Amsterdam (ACTA) MOVE Research Institute Amsterdam University of Amsterdam and VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6677-7897","authenticated-orcid":false,"given":"G.","family":"Aarab","sequence":"additional","affiliation":[{"name":"Department of Oral Kinesiology Academic Centre for Dentistry Amsterdam (ACTA) MOVE Research Institute Amsterdam University of Amsterdam and VU University Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140070"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.01.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000096"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319595"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.2.240"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0513-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.1999.00153.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.02.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3226"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.05.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.2051"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324580"},{"key":"e_1_2_8_16_1","first-page":"301","article-title":"Use of the research diagnostic criteria for temporomandibular disorders for multinational research: translation efforts and reliability assessments in The Netherlands","volume":"19","author":"Lobbezoo F","year":"2005","journal-title":"J Orofac Pain"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0298-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000167790"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.1.30"},{"key":"e_1_2_8_20_1","first-page":"117","article-title":"Creation of the \u201cASDC sleep disorders questionnaire\u201d","volume":"15","author":"Douglass AB","year":"1986","journal-title":"Sleep Res"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(98)00030-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.03.017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3004"},{"key":"e_1_2_8_24_1","first-page":"608","article-title":"Excessive daytime sleepiness in sleep disorders","volume":"4","author":"Slater G","year":"2012","journal-title":"J Thorac Dis"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479972312473134"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.33588\/rn.3006.99584","article-title":"Accidents prevalence in a group of patients with the narcolepsy\u2010cataplexy syndrome","volume":"30","author":"Le\u00f3n\u2010Mu\u00f1oz L","year":"2000","journal-title":"Rev Neurol"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/18.6.463"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1205-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2008.01893.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27772"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03610.x"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoor.12505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.12505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T17:21:09Z","timestamp":1750094469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.12505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/joor.12505"],"URL":"https:\/\/doi.org\/10.1111\/joor.12505","archive":["Portico"],"relation":{},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]}}}