{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:38:24Z","timestamp":1787881104515,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aims of this study were to assess sensory recovery and impact on life quality after tongue reconstruction of oncological defects using different flap types. Thirty\u2010two patients who underwent tongue reconstruction for oncological defects 9\u00b73 months after surgery with non\u2010innervated radial forearm free flaps (<jats:styled-content style=\"fixed-case\">RFFF<\/jats:styled-content>s) (<jats:italic>N<\/jats:italic> = 16), non\u2010innervated anterolateral thigh free flaps (<jats:styled-content style=\"fixed-case\">ALTFF<\/jats:styled-content>s) (<jats:italic>N<\/jats:italic> = 8) and nasolabial island flaps (<jats:styled-content style=\"fixed-case\">NLIF<\/jats:styled-content>s) (<jats:italic>N<\/jats:italic> = 8), and 20 age\u2010 and gender\u2010matched healthy controls participated in the study. The modalities assessed were cold detection threshold, warm detection threshold (<jats:styled-content style=\"fixed-case\">WDT<\/jats:styled-content>), cold pain threshold, heat pain threshold (<jats:styled-content style=\"fixed-case\">HPT<\/jats:styled-content>), mechanical detection threshold (<jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content>), mechanical pain threshold (<jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content>) and the Chinese version of Oral Health Impact Profile\u201049. <jats:styled-content style=\"fixed-case\">ALTFF<\/jats:styled-content>s was significantly more sensitive than <jats:styled-content style=\"fixed-case\">RFFF<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> = 0\u00b7005) and <jats:styled-content style=\"fixed-case\">NLIF<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> = 0\u00b7014) for <jats:styled-content style=\"fixed-case\">WDT<\/jats:styled-content>, and showed a better sensory recovery than <jats:styled-content style=\"fixed-case\">RFFF<\/jats:styled-content>s for <jats:styled-content style=\"fixed-case\">HPT<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0\u00b7011). <jats:styled-content style=\"fixed-case\">ALTFF<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">NLIF<\/jats:styled-content>s showed significantly better sensory recovery than <jats:styled-content style=\"fixed-case\">RFFF<\/jats:styled-content>s for <jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0\u00b7005). <jats:styled-content style=\"fixed-case\">NLIF<\/jats:styled-content>s showed the best sensory recovery for <jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content>, followed by <jats:styled-content style=\"fixed-case\">ALTFF<\/jats:styled-content>s and lastly <jats:styled-content style=\"fixed-case\">RFFF<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> = 0\u00b7004). <jats:styled-content style=\"fixed-case\">NLIF<\/jats:styled-content>s also showed the least impact on quality of life measures related to psychological discomfort compared to <jats:styled-content style=\"fixed-case\">RFFF<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">ALTFF<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> &lt; 0\u00b7019). All modalities of sensory recovery in <jats:styled-content style=\"fixed-case\">RFFF<\/jats:styled-content>s did not depend on gender and post\u2010operative radiotherapy (<jats:italic>P<\/jats:italic> &gt; 0\u00b705). Different flaps for tongue reconstruction of oncological defects appear to have different patterns of sensory recovery and impact on quality of life measures. A longer follow\u2010up period and larger number of participants will be needed in future studies.<\/jats:p>","DOI":"10.1111\/joor.12510","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T18:42:20Z","timestamp":1490726540000},"page":"736-748","source":"Crossref","is-referenced-by-count":17,"title":["Sensory recovery of non\u2010innervated free flaps and nasolabial island flaps used for tongue reconstruction of oncological defects"],"prefix":"10.1111","volume":"44","author":[{"given":"L.","family":"Zhu","sequence":"first","affiliation":[{"name":"Orofacial Pain &amp; TMD Research Unit Institute of Stomatology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"},{"name":"Institute of Stomatology &amp; Department of Orthodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"},{"name":"Department of Stomatology The Children's Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Orofacial Pain &amp; TMD Research Unit Institute of Stomatology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Stomatology &amp; Department of Oral and Maxillofacial Surgery Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Hou","sequence":"additional","affiliation":[{"name":"Orofacial Pain &amp; TMD Research Unit Institute of Stomatology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"},{"name":"Institute of Stomatology &amp; Department of Orthodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Orofacial Pain &amp; TMD Research Unit Institute of Stomatology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"},{"name":"Institute of Stomatology &amp; Department of Orthodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9858-4961","authenticated-orcid":false,"given":"W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Orofacial Pain &amp; TMD Research Unit Institute of Stomatology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"},{"name":"Institute of Stomatology &amp; Department of Orthodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Section of Orofacial Pain and Jaw Function School of Dentistry and Oral Health Aarhus University Aarhus Denmark"},{"name":"Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Orofacial Pain &amp; 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