{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:25:31Z","timestamp":1793179531641,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01\u2010DE15420"],"award-info":[{"award-number":["R01\u2010DE15420"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Summary<\/jats:title>Evidence\u2010based clinical diagnostic criteria for temporomandibular joint (TMJ<\/jats:styled-content>) arthritis are not available. To establish (i) criteria for clinical diagnosis of TMJ<\/jats:styled-content> arthritis and (ii) clinical variables useful to determine inflammatory activity in TMJ<\/jats:styled-content> arthritis using synovial fluid levels of inflammatory mediators as the reference standard. A calibrated examiner assessed TMJ<\/jats:styled-content> pain, function, noise and occlusal changes in 219 TMJ<\/jats:styled-content>s (141 patients, 15 healthy individuals). TMJ<\/jats:styled-content> synovial fluid samples were obtained with a push\u2013pull technique using the hydroxycobalamin method and analysed for TNF<\/jats:styled-content>, TNF<\/jats:styled-content>sRII<\/jats:styled-content>, IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20101ra, IL<\/jats:styled-content>\u20101sRII<\/jats:styled-content>, IL<\/jats:styled-content>\u20106 and serotonin. If any inflammatory mediator concentration exceeded normal, the TMJ<\/jats:styled-content> was considered as arthritic. In the patient group, 71% of the joints were arthritic. Of those, 93% were painful. About 66% of the non\u2010arthritic TMJ<\/jats:styled-content>s were painful to some degree. Intensity of TMJ<\/jats:styled-content> resting pain and TMJ<\/jats:styled-content> maximum opening pain, number of jaw movements causing TMJ<\/jats:styled-content> pain and laterotrusive movement to the contralateral side significantly explained presence of arthritis (AUC<\/jats:styled-content> 0.72, P<\/jats:italic>\u00a0<\u00a0.001). Based on these findings, criteria for possible, probable and definite TMJ<\/jats:styled-content> arthritis were determined. Arthritic TMJ<\/jats:styled-content>s with high inflammatory activity showed higher pain intensity on maximum mouth opening (P<\/jats:italic>\u00a0<\u00a0.001) and higher number of painful mandibular movements (P<\/jats:italic>\u00a0=\u00a0.004) than TMJ<\/jats:styled-content>s with low inflammatory activity. The combination TMJ<\/jats:styled-content> pain on maximum mouth opening<\/jats:italic> and Contralateral laterotrusion <8\u00a0mm<\/jats:italic> appears to have diagnostic value for TMJ<\/jats:styled-content> arthritis. Among arthritic TMJ<\/jats:styled-content>s, higher TMJ<\/jats:styled-content> pain intensity on maximum mouth opening and number of mandibular movements causing TMJ<\/jats:styled-content> pain indicates higher inflammatory activity.<\/jats:p>","DOI":"10.1111\/joor.12611","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T08:58:39Z","timestamp":1517561919000},"page":"269-281","source":"Crossref","is-referenced-by-count":42,"title":["Clinical diagnosis of temporomandibular joint arthritis"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-7742","authenticated-orcid":false,"given":"P.","family":"Alstergren","sequence":"first","affiliation":[{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Malm\u00f6 Sweden"},{"name":"Specialized Pain Rehabilitation Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Orofacial Pain Unit Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"},{"name":"Section for Orofacial Pain and Jaw Function Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7989-1541","authenticated-orcid":false,"given":"M.","family":"Pigg","sequence":"additional","affiliation":[{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Malm\u00f6 Sweden"},{"name":"Department of Endodontics Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kopp","sequence":"additional","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2012.03.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.09.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748909099929"},{"key":"e_1_2_7_5_1","first-page":"71","article-title":"Craniomandibular function in juvenile chronic arthritis. 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