{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:39:02Z","timestamp":1790692742172,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006366","name":"Minist\u00e9rio da Educa\u00e7\u00e3o","doi-asserted-by":"publisher","award":["1693008"],"award-info":[{"award-number":["1693008"]}],"id":[{"id":"10.13039\/501100006366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The purpose of this study was to systematically review the literature for studies that assessed the effects of glucosamine supplements (<jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content>) on pain and maximum mouth opening (<jats:styled-content style=\"fixed-case\">MMO<\/jats:styled-content>) restriction compared to other therapies, placebo or no intervention on painful temporomandibular joint osteoarthritis (<jats:styled-content style=\"fixed-case\">TMJ OA<\/jats:styled-content>). Randomised controlled trials were selected in a two\u2010phase process. Seven electronic databases, in addition to three grey literature databases, were searched. Risk of bias was assessed using the Cochrane Collaboration's tool for assessing risk of bias in randomised trials. Twelve potentially eligible studies were identified, from which three were finally included. Furthermore, two were categorised at low risk and one at high risk of bias. Intervention groups were treated with glucosamine\u2010sulphate, while controls were treated with placebo or ibuprofen. In two studies, <jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content> were equally effective regarding pain reduction and mouth opening improvement compared to ibuprofen taken two or three times a day over 12\u00a0weeks; however, one study did not find significant differences in follow\u2010up evaluations concerning these clinical variables in both glucosamine and placebo groups administered over six weeks. There is very low evidence regarding <jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content> therapeutic effects on <jats:styled-content style=\"fixed-case\">TMJ OA<\/jats:styled-content>. Considering a follow\u2010up of 12\u00a0weeks, <jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content> were as effective as ibuprofen taken two or three times a day. However, over six weeks of medication intake, <jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content> were not superior to placebo. Still, included studies presented major drawbacks, and therefore, conclusions must be interpreted with caution.<\/jats:p>","DOI":"10.1111\/joor.12616","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T13:22:50Z","timestamp":1518700970000},"page":"414-422","source":"Crossref","is-referenced-by-count":16,"title":["Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-4954","authenticated-orcid":false,"given":"G.","family":"Melo","sequence":"first","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina (UFSC)  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Casett","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina (UFSC)  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stuginski\u2010Barbosa","sequence":"additional","affiliation":[{"name":"Department of Dentistry Bauru School of Dentistry University of S\u00e3o Paulo (USP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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L.","family":"Porporatti","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina (UFSC)  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Flores\u2010Mir","sequence":"additional","affiliation":[{"name":"School of Dentistry Faculty of Medicine and Dentistry University of Alberta  Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"De Luca Canto","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Santa Catarina (UFSC)  Florian\u00f3polis Santa Catarina 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