{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:39:14Z","timestamp":1791088754896,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ZENKYOREN (National Mutual Insurance Federation of Agricultural Cooperatives) of Japan","award":["0023"],"award-info":[{"award-number":["0023"]}]},{"name":"ZENKYOREN (National Mutual Insurance Federation of Agricultural Cooperatives) of Japan","award":["2015"],"award-info":[{"award-number":["2015"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Arthrocentesis has an effect of washing out inflammatory products that accumulate in the joint compartment of a dysfunctional temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>). The procedure removes inflammatory cytokines, which are pain\u2010causing substances, for early reduction of <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> pain and quick recovery of jaw function, thus increasing the possibility of a successful rehabilitation. The aim of this study was to investigate the relationship between arthroscopy synovitis grade in patients with unilateral high condylar fractures and concentrations of the pro\u2010inflammatory cytokines tumour necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010alpha as well as of matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s) in washed\u2010out synovial fluid (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>) samples obtained from those patients. A total of 26 patients with unilateral high condylar fractures who underwent arthrocentesis for a therapeutic purpose were examined. <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> samples were collected before performing arthroscopy to determine synovitis grade. The detection rates and concentrations of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s were determined, and their association with synovitis grade was analysed. <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha was detected in 23 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 in 22 of the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s. There was a correlation between synovitis grade and concentration of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha in the fracture group. Furthermore, the concentrations of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 were significantly higher as compared to the control group, comprised of <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s on the non\u2010fracture side of the same patients, while a correlation was also noted between <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha concentration and synovitis grade in the fracture group. The present findings may provide a biological\/biochemical rationale for arthrocentesis as a reasonable treatment modality for high condylar fractures.<\/jats:p>","DOI":"10.1111\/joor.12632","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:14:44Z","timestamp":1523938484000},"page":"452-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Relationship between arthroscopic findings of synovitis and levels of tumour necrosis factor\u2010alpha and matrix metalloproteinases in synovial lavage fluid from patients with unilateral high mandibular condyle fractures"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5885-9529","authenticated-orcid":false,"given":"S.","family":"Nogami","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery Department of Oral Medicine, and Surgery Tohoku University Graduate School of Dentistry  Sendai Miyagi Japan"},{"name":"Department of Oral and Maxillofacial Surgery Salzburg Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery Department of Oral Medicine, and Surgery Tohoku University Graduate School of Dentistry  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery Department of Oral Medicine, and Surgery Tohoku University Graduate School of Dentistry  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery Department of Oral Medicine, and Surgery Tohoku University Graduate School of Dentistry  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery Nihon University School of Dentistry at Matsudo  Matsudo Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chiba","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Surgery Department of Oral Medicine, and Surgery Tohoku University Graduate School of Dentistry  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gaggl","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Salzburg Paracelsus Medical University  Salzburg 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