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Duct obstruction is closely correlated with <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content>, and partial duct obstruction is usually observed in <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content>. Partial ligation of ducts or vessels is a valid treatment to mimic pathological processes in certain animal studies. In this study, we developed a novel animal model of <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content> by incomplete ligation of Wharton's duct and clarified the corresponding morphological alterations in the submandibular gland. Partial ligation of Wharton's duct in Japanese white rabbits resulted in a gradually progressive <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content> model as demonstrated by sialographic, gross, microscopic, and ultrastructural changes in acinar and ductal degenerations over 8\u00a0weeks. The model is a feasible option for investigating the pathogenesis of <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content> and evaluating the efficacy and safety of novel treatments of <jats:styled-content style=\"fixed-case\">COS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/joor.12711","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:00:44Z","timestamp":1534950044000},"page":"983-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An experimental chronic obstructive sialadenitis model by partial ligation of the submandibular duct characterised by sialography, histology, and transmission electron microscopy"],"prefix":"10.1111","volume":"45","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School &amp; Hospital of Stomatology Wuhan University  Wuhan Hubei China"},{"name":"Department of Oral Radiology of School &amp; Hospital of Stomatology Wuhan University  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wei","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) &amp; Key Laboratory of Oral Biomedicine Ministry of Education School &amp; Hospital of Stomatology Wuhan University  Wuhan Hubei China"},{"name":"Department of Oral Radiology of School &amp; Hospital of Stomatology Wuhan University  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Radiology of School &amp; Hospital of Stomatology Wuhan University  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangwen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Oral Radiology of School &amp; 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