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In addition, we evaluated levels of BDNF<\/jats:styled-content>, NGF<\/jats:styled-content>, IL<\/jats:styled-content>\u201010 and IL<\/jats:styled-content>\u20106 in the brainstem and blood serum of these animals at 24\u00a0hours and 7\u00a0days after the end of tDCS<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>Methods<\/jats:title>Rats were subjected to temporomandibular joint pain and treated with tDCS<\/jats:styled-content>. The animals were divided into control, pain and pain + treatment groups. Mechanical and thermal hyperalgesia were evaluated at baseline, 7\u00a0days after administration of complete Freund's adjuvant, and immediately, 24\u00a0hours, and 7\u00a0days after the tDCS<\/jats:styled-content> treatment. Neuroimmunomodulators levels were determined by ELISA<\/jats:styled-content>. Statistical analyses were performed by (GEE<\/jats:styled-content>)\/Bonferroni (behavioural tests), three\u2010way ANOVA<\/jats:styled-content>\/SNK<\/jats:styled-content> (neurochemical tests) and Kruskal\u2010Wallis (histological analysis).<\/jats:p><\/jats:sec>Results<\/jats:title>Transcranial direct\u2010current stimulation reduced mechanical and thermal hyperalgesia (P<\/jats:italic>\u00a0<\u00a00.01). We observed interaction between factors (pain and treatment) increasing brainstem BDNF<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.01) and NGF<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.05) levels. Furthermore, we found an increase in IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u201010 levels in the brainstem at 24\u00a0hours and 7\u00a0days after tDCS<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We showed that tDCS<\/jats:styled-content> reduces thermal and mechanical hyperalgesia induced by orofacial pain until 7\u00a0days after treatment. 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