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Therefore, critical factors have been grouped into three major categories: (a) the natural course of the diseases; (b) the regression of the symptoms to their mean intensity; and (c) placebo response. This topical narrative review describes the elements mentioned above, provides an up\u2010to\u2010date overview of the hot topics and gaps in the field and indicates developing and future research direction of the orofacial pain field. Such a knowledge might be positively used during daily clinical practice to optimise the management of orofacial pain diseases, as well as in conducting future clinical trials for validating new interventions.<\/jats:p>","DOI":"10.1111\/joor.12736","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T16:06:53Z","timestamp":1539706013000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ancillary factors in the treatment of orofacial pain: A topical narrative review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-0224","authenticated-orcid":false,"given":"Marcello","family":"Melis","sequence":"first","affiliation":[{"name":"Private practice  Cagliari Italy"},{"name":"School of Dentistry University of Cagliari  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Di Giosia","sequence":"additional","affiliation":[{"name":"Orofacial Pain Clinic Department of Endodontics Center for Pain Research and Innovation School of Dentistry University of North Carolina  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Colloca","sequence":"additional","affiliation":[{"name":"Department of Pain and Translational Symptom Science &amp; 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