{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:07:09Z","timestamp":1777860429422,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to examine whether oral health as an infection focus could mediate disease course in patients with Beh\u00e7et's disease (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the study, oral health of 194 BD patients was examined at baseline and follow\u2010up periods. The reasons for last dental visits were recorded as tooth extraction or regular control visits\/planned treatments at the end of follow\u2010up period. The Beh\u00e7et's disease severity score was calculated with higher scores indicating a more severe course. Mediation analysis was carried out to assess the effects of oral health on disease severity score at follow\u2010up period in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dental and periodontal indices were found to be higher at follow\u2010up visit compared to those of baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Disease severity score was found to be higher in males (5.3\u00a0\u00b1\u00a02.4) compared to females (4.4\u00a0\u00b12.5) in the whole group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). Moreover, patients having tooth extraction at their last dental visit and patients with dental caries had a more severe disease course (5.4\u00a0\u00b1\u00a02.4; 5.5\u00a0\u00b1\u00a02.5) compared to others (4.2\u00a0\u00b1\u00a02.3; 4.4\u00a0\u00b1\u00a02.4; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). In multiple mediation analysis, disease severity score was a dependent variable and was directly mediated by male gender (<jats:italic>B<\/jats:italic>\u00a0=\u00a0\u22120.8822, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0145) and indirectly mediated through the presence of dental caries (<jats:italic>B<\/jats:italic>\u00a0=\u00a00.9509 <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0110) and need of tooth extraction (<jats:italic>B<\/jats:italic>\u00a0=\u00a00.8758, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0128).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both presence of dental caries and need of tooth extraction were observed to be effective mediators for a more severe disease course in BD. Therefore, better oral health should be aimed to eliminate microbial factors, which are a part of pathogenic processes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.12750","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T14:42:42Z","timestamp":1542897762000},"page":"349-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oral health is a mediator for disease severity in patients with Beh\u00e7et\u2019s disease: A multiple mediation analysis study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-8719","authenticated-orcid":false,"given":"Meral","family":"Yay","sequence":"first","affiliation":[{"name":"Department of Statistics Mimar Sinan Fine Arts University Istanbul 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