{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:09:11Z","timestamp":1785420551787,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Temporomandibular disorder (TMD) is a multifactorial condition involving environmental, psychological and genetic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this case\u2010control study was to evaluate the influence of genetic polymorphisms in <jats:italic>5HTT<\/jats:italic> and <jats:italic>COMT<\/jats:italic> on TMD and anxiety in adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TMD was diagnosed and classified according to the RDC\/TMD criteria. For case group, the following TMD categories were used: myofascial pain, disc displacement, arthralgia and painful TMD (myofascial and arthralgia). Anxiety levels were assessed according to the State\u2010Trait Anxiety Inventory. Genomic DNA was extracted, and genetic polymorphisms were genotyped by TaqMan chemistry and endpoint analysis. Logistic multivariate regression was used to analyse the associations between TMD types and genotypes, anxiety level and genotypes, using an adjusted odds ratio (OR<jats:sub>a<\/jats:sub>; CI 95%) that considered the gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In <jats:italic>5HTT<\/jats:italic>, the rs1042173 was associated with painful TMD (arthralgia and myofascial pain) (OR<jats:sub>c<\/jats:sub>\u00a0=\u00a01.97; CI 95%: 1.02\u20103.77; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Polymorphisms in <jats:italic>COMT<\/jats:italic> rs4818 were significantly associated with myofascial pain (OR<jats:sub>c<\/jats:sub>\u00a0=\u00a02.15; CI 95%: 1.08\u20104.29; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and were borderline for painful TMD (OR<jats:sub>c<\/jats:sub>\u00a0=\u00a01.85; CI 95%: 0.97\u20103.51; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) and disc displacement (OR<jats:sub>c<\/jats:sub>\u00a0=\u00a02.42; CI 95%: 1.00\u20105.87; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05). The rs6269 was borderline for myofascial pain (OR<jats:sub>c<\/jats:sub>\u00a0=\u00a01.82; CI 95%: 0.92\u20103.59; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08) and disc displacement (OR<jats:sub>c<\/jats:sub>\u00a0=\u00a02.38; CI 95% 0.95\u20105.97; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) and also was associated with anxiety (OR<jats:sub>a<\/jats:sub>\u00a0=\u00a02.34; CI 95% 1.04\u20105.25; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Polymorphisms in <jats:italic>5HTT<\/jats:italic> and <jats:italic>COMT<\/jats:italic> are associated with TMD in adolescents. Moreover, polymorphism in <jats:italic>COMT <\/jats:italic>is associated with anxiety in adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.12783","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T01:15:38Z","timestamp":1551316538000},"page":"597-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The association of genetic polymorphisms in serotonin transporter and catechol\u2010O\u2010methyltransferase on temporomandibular disorders and anxiety in adolescents"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-702X","authenticated-orcid":false,"given":"Jo\u00e3o Armando","family":"Brancher","sequence":"first","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Porto","family":"Spada","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Nascimento","family":"Meger","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aluhe Lopes","family":"Fatturri","sequence":"additional","affiliation":[{"name":"Department of Stomatology Universidade Federal do Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Dalledone","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Mara","family":"de Paiva Bertoli","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Deeley","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Scariot","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidade Positivo Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Rezende","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dental Medicine University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Feltrin","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Stomatology Universidade Federal do Paran\u00e1 Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0642-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7152.190"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.01.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-05822013000400018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2015.07.017"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"6","article-title":"Prevalence of symptoms and signs indicative of temporomandibular disorders in children and adolescents. 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