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GJL was assessed using the Beighton test. Maximum mouth opening (MMO) and clinical clicking sounds as signs of disc displacement (DD) in the TMJ were assessed according to the Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD). Serum levels of sex hormones were assessed using standardised laboratory analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hypermobile joints were found in 54.9% (N\u00a0=\u00a0532) of the sample; females were more affected than males (61.4% vs. 51.8%,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Using logistic regression analyses, the odds ratio (OR) for having &gt;1 hypermobile joints increased to 1.15 (95% confidence interval [CI]: 1.04\u20101.27) in males and 1.09 (95% CI: 1.02\u20101.17) in females per 10 units of the SHBG serum level, compared to those without hypermobile joints\u2014after controlling for the effect of age, adjusted BMI, pubertal development (Tanner scale), testosterone as well as oestradiol levels. Female subjects with &gt;1 hypermobile joints showed a higher OR (1.89; 95% CI: 1.05\u20103.43) for having clinical clicking sounds in the TMJ and a 3.28 times higher OR (95% CI: 1.44\u20107.44) for MMO\u00a0\u2265\u00a055\u00a0mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed age\u2010 and gender\u2010independent associations of higher SHBG serum levels with GJL in adolescents. Moreover, hypermobile female adolescents show a more frequent hypermobility of the TMJ and clinical signs of DD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.12834","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T15:57:39Z","timestamp":1560787059000},"page":"1023-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sex hormones in association with general joint laxity and hypermobility in the temporomandibular joint in adolescents\u2014results of the epidemiologic LIFE child study"],"prefix":"10.1111","volume":"46","author":[{"given":"Caroline","family":"Graf","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Materials Science University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-3739","authenticated-orcid":false,"given":"Oliver","family":"Schierz","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Materials Science University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Steinke","sequence":"additional","affiliation":[{"name":"Institute of Anatomy University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center for Civilization Diseases University of Leipzig Leipzig Germany"},{"name":"Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL) University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieland","family":"Kiess","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center for Civilization Diseases University of Leipzig Leipzig Germany"},{"name":"Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL) University of Leipzig Leipzig Germany"},{"name":"Integrated Research and Treatment Center Adiposity Diseases University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Kratzsch","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hirsch","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center for Civilization Diseases University of Leipzig Leipzig Germany"},{"name":"Clinic of Pediatric Dentistry University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Life Child Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"143","article-title":"Prevalence of signs and symptoms of temporomandibular disorders in an urban and rural German population. 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