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This placebo\u2010controlled crossover investigation compared the somatosensory profile following topical anaesthesia between TMD patients (n\u00a0=\u00a020) and healthy participants (n\u00a0=\u00a020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cold detection threshold, warm detection threshold, cold pain threshold, heat pain threshold, mechanical detection threshold, mechanical pain threshold, wind\u2010up ratio and pressure pain threshold were assessed on the skin overlying the masseter at three consecutive days (baseline and immediately after lidocaine 4%\/placebo cream). Mixed ANOVA and a coding system that accounts for the diversity of types of peripheral axons associated with the somatosensory parameters were applied for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lidocaine application caused no changes in the somatosensory sensitivity in the masseter region in TMD patients (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.050), but sensitivity to cold, cold pain, touch and pinprick stimuli were reduced after topical anaesthesia in healthy participants (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.050). Also, the degree of topical anaesthesia was greater in healthy participants (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). The coding system suggested that TMD patients presented only A\u03b4\u2010fibre block, whereas a combination of either A\u03b2\u2010 and\/or C\u2010fibre block was observed in 35% of healthy participants in addition to A\u03b4\u2010fibre block following lidocaine application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quantitative sensory testing can be successfully applied to identify meaningful differences in the degree of hypoalgesia and hypoesthesia following short\u2010time topical anaesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.12874","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:51:28Z","timestamp":1565959888000},"page":"113-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Topical anaesthesia degree is reduced in temporomandibular disorders patients: A novel approach to assess underlying mechanisms of the somatosensory alterations"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-5020","authenticated-orcid":false,"given":"Yuri Martins","family":"Costa","sequence":"first","affiliation":[{"name":"Section of Head and Face Physiology Department of Biological Sciences Bauru School of Dentistry University of Sao Paulo Bauru Brazil"},{"name":"Bauru Orofacial Pain Group Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyna Mara A. 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