{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:34:17Z","timestamp":1790656457343,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is no consensus regarding the most effective anaesthetic solution for children; nerve block, especially mandibular, can be difficult for general dentists. Therefore, the study aims to compare the efficacy and the adverse events of articaine 4% with epinephrine 1:100\u00a0000 with lidocaine 2% with epinephrine 1:100\u00a0000 for primary molar extraction using buccal infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>These are data from a parallel triple\u2010blind randomised controlled trial with a computer\u2010generated allocation treatment. Forty\u2010three children aged 6\u201010\u00a0years with a clinical and radiographic indication of primary molar extraction were enrolled. The intervention was local buccal infiltration with articaine 4% compared with lidocaine 2%. The main outcome was pain during anaesthetic injection and tooth extraction. Adverse events were examined as secondary outcomes. Children were treated in a University setting from April to June 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both solutions had similar anaesthetic efficacy in primary molar extraction when applied by the infiltrative technique (\u03b2 \u22120.47; 95% CI \u22123.19 to 2.24;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.76); however, children reported higher mean pain during articaine deposition (\u03b2 2.43; 95% CI 0.28\u20104.57;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02). The measured lidocaine pH was 3.19 (0.15) and articaine was 2.43 (0.00) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04). Post\u2010operative pain, oedema and nausea were observed without differences between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no difference in the efficacy of articaine compared to lidocaine for primary molar extraction. Articaine was more painful during the injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Practical implications<\/jats:title>\n                    <jats:p>Primary molar extractions can be performed with both articaine and lidocaine buccal infiltration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.12989","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T02:04:31Z","timestamp":1588903471000},"page":"1031-1040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and adverse events of 4% articaine compared with 2% lidocaine on primary molar extraction: A randomised controlled trial"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-055X","authenticated-orcid":false,"given":"Carla","family":"Massignan","sequence":"first","affiliation":[{"name":"Department 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-9061","authenticated-orcid":false,"given":"Michele","family":"Bolan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry School of Dentistry Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"214","volume-title":"Classification of Chronic Pain","author":"Merskey 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