{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:38Z","timestamp":1787015678992,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870788"],"award-info":[{"award-number":["81870788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Degenerative joint disease (DJD) of the temporomandibular joints (TMJs) in adolescents and young adults is closely associated with disc displacement without reduction (DDw\/oR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine the pathogenesis of early\u2010stage TMJ DJD induced by DDw\/oR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>31 female subjects aged 12\u201030\u00a0years were enrolled, comprising 12 patients with DDw\/oR without DJD, 13 with DDw\/oR and early\u2010stage DJD, and 6 healthy volunteers. The synovial fluid samples of the subjects were screened for 27 inflammatory\u2010related cytokines using multiple cytokine array. Significantly increased cytokines and a key regulator of osteoclastogenesis \u201creceptor activator of nuclear factor\u2010\u03baB ligand\u201d (RANKL) were further determined by sandwich immunoassay. These factors were also assessed for the possible pathophysiologic actions on RAW264.7 cell proliferation, migration, osteoclastogenesis and bone\u2010resorbing activity using Cell Counting Kit\u20108, Transwell system, tartrate\u2010resistant acid phosphatase staining and osteo assay plates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Macrophage\u2010derived inflammatory protein\u20101 beta (MIP\u20101\u03b2) and regulated upon activation normal T cell expressed and secreted (RANTES) were found to vary significantly in relation to the controls. In contrast to an unchanged concentration of RANKL, a strong increase in the level of RANTES was detected in subjects with DDw\/oR and early\u2010stage DJD. MIP\u20101\u03b2 concentrations were only elevated in subjects with DDw\/oR without DJD. Functionally, both MIP\u20101\u03b2 and RANTES could enhance macrophage migration in a concentration\u2010dependent manner, while only RANTES exhibited a promoting effect on osteoclast formation and bone\u2010resorbing activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chemokine RANTES was significantly upregulated and might be a key regulator of osteoclastogenesis contributing to DDw\/oR\u2010induced early\u2010stage TMJ DJD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13041","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T12:39:03Z","timestamp":1593607143000},"page":"1150-1160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Increased chemokine RANTES in synovial fluid and its role in early\u2010stage degenerative temporomandibular joint disease"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-9761","authenticated-orcid":false,"given":"Shi\u2010Yang","family":"Feng","sequence":"first","affiliation":[{"name":"Center for TMD &amp; Orofacial Pain Peking University School &amp; Hospital of Stomatology Beijing China"},{"name":"National Clinical Research Center for Oral Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-4436","authenticated-orcid":false,"given":"Jie","family":"Lei","sequence":"additional","affiliation":[{"name":"Center for TMD &amp; Orofacial Pain Peking University School &amp; Hospital of Stomatology Beijing China"},{"name":"National Clinical Research Center for Oral Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Min","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Oral Diseases Beijing 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