{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:04Z","timestamp":1772160724433,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It has been suggested that botulinum toxin A (BONT\u2010A) is a safe and effective treatment in relieving pain in patients with persistent idiopathic dentoalveolar pain (PIDP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to systematically evaluate all the available studies investigating the pain\u2010relieving effects of BONT\u2010A in patients with PIDP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search with specific search terms was made in PubMed, Web of Science and Scopus. Two authors screened titles and abstracts and selected eligible studies for inclusion in the systematic review. The quality of the studies was evaluated by the 12 items Quality Assessment Tool for Observational studies (Pre\u2010Post) Studies with No Control Group, and the level of evidence was assessed according to GRADE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three observational studies of 3695 identified were included (445 overlapping studies; 3247 excluded studies). All studies were uncontrolled observational studies investigating the pain\u2010relieving effect of BONT\u2010A in patients with PIDP. The included studies had a fair quality (moderate risk of bias) and insufficient level of evidence. The pain reducing effect by BONT\u2010A injections was in average 50% or more in two studies, in one study 3 out of 4 patients became almost pain free.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review shows that presently the level of scientific evidence is insufficient to evaluate the pain\u2010relieving effect of BONT\u2010A injections in patients with PIDP. There are indications that BONT\u2010A injections could be a possible management option for patients with PIDP that seems to be safe and with few adverse events. There is a need for well\u2010designed placebo\u2010controlled, double\u2010blind RCTs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13053","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T16:40:22Z","timestamp":1594226422000},"page":"1184-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The effect of botulinum toxin A on patients with persistent idiopathic dentoalveolar pain\u2014A systematic review"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-6803","authenticated-orcid":false,"given":"Andreas","family":"Dawson","sequence":"first","affiliation":[{"name":"Centre for Oral Rehabilitation \u00d6sterg\u00f6tland County Council Link\u00f6ping Sweden"},{"name":"Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"},{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Dawson","sequence":"additional","affiliation":[{"name":"Centre for Oral Rehabilitation \u00d6sterg\u00f6tland County Council Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4152-5439","authenticated-orcid":false,"given":"Malin","family":"Ernberg","sequence":"additional","affiliation":[{"name":"Scandinavian Center for Orofacial Neurosciences (SCON) Huddinge Sweden"},{"name":"Division of Oral Diagnostics and Rehabilitation Department of Dental Medicine Karolinska Institutet Scandinavian Center for Orofacial Neuroscience (SCON) Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419893823"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2011.02247.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.11.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.09.009"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"172","article-title":"A unified concept of idiopathic orofacial pain: clinical features","volume":"13","author":"Woda A","year":"1999","journal-title":"J Orofac Pain"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01923.x"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"89","article-title":"Clinical findings and psychosocial factors in patients with atypical odontalgia: a case\u2010control study","volume":"21","author":"List T","year":"2007","journal-title":"J Orofac Pain"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.05.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1230"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-006-0358-1"},{"key":"e_1_2_8_12_1","first-page":"699","article-title":"Psychiatric diagnoses in patients with burning mouth syndrome and atypical odontalgia referred from psychiatric to dental facilities","volume":"6","author":"Takenoshita M","year":"2010","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/413515"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02999.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2006.12222229"},{"issue":"1","key":"e_1_2_8_16_1","first-page":"30","article-title":"Diagnosing and treating atypical odontalgia","volume":"44","author":"Brooke RI","year":"1995","journal-title":"J Mass Dent Soc"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-8-3-81"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90322-H"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0146"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw040"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S169701"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.2031"},{"issue":"3","key":"e_1_2_8_23_1","first-page":"e123","article-title":"Preferred reporting items for systematic reviews and meta\u2010analyses: the PRISMA Statement","volume":"3","author":"Moher D","year":"2009","journal-title":"Open Med"},{"key":"e_1_2_8_24_1","unstructured":"HigginsJPT G.S.Cochrane handbook for systematic reviews of interventions version 5.1.0: Cochrane Collaboration 2011. 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