{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:45:21Z","timestamp":1783608321177,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Intra\u2010articular analgesics are increasingly being used after temporomandibular joint (TMJ) arthrocentesis but without clear evidence on its efficacy. The aim of this study was to review the role of intra\u2010articular analgesic injected after TMJ arthrocentesis in improving post\u2010operative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase, Scopus, BioMed Central, CENTRAL and Google Scholar databases were searched from inception up to 15th April 2020. Randomised controlled trials (RCTs) on adult patients with temporomandibular joint disorders (TMDs) comparing any intra\u2010articular analgesic with control after arthrocentesis were included. Risk of bias was assessed by Cochrane Collaboration\u2019s Risk of Bias\u20102 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine RCTs were included. Four studies used non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) and five used opioids after arthrocentesis. Descriptive analysis of NSAID studies indicated that intra\u2010articular NSAIDs may not improve pain and maximal mouth opening (MMO) after TMJ arthrocentesis. Meta\u2010analysis indicated a statistically significant reduction of pain with the use of opioids at 1\u00a0week, 1, 3, and 6\u00a0months. Similarly, MMO was significantly improved with intra\u2010articular opioids at 1\u00a0week, 1 and 6\u00a0months. Data were analysed from a limited number of studies with a small sample size. The quality of the included studies was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low\u2010quality evidence suggests that intra\u2010articular NSAIDs may have no effect on pain and MMO after TMJ arthrocentesis. Intra\u2010articular opioids may improve pain and MMO at short\u2010term follow\u2010up. Results are to be interpreted with caution considering several limitations of the review. Further high\u2010quality trials with large sample size are needed to provide better evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13105","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T13:12:51Z","timestamp":1601557971000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Do intra\u2010articular injections of analgesics improve outcomes after temporomandibular joint arthrocentesis?: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9091-4997","authenticated-orcid":false,"given":"Siyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Stomatology Affiliated Hospital of Shaoxing University Shaoxing 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