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In addition, the topic of iatrogenesis is discussed as a major contributor to the negative outcomes that can be seen in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the patient level, anatomical, psychosocial and genetic factors may contribute to individual vulnerability. The anatomy and pathophysiology of muscles, joints, disc and nerves may all be involved in predisposing to TMD symptoms, especially when the patients have pain elsewhere in the body. Among the psychosocial factors, some features may be elucidated by the DC\/TMD axis II, while others (eg illness behaviour, Munchausen syndrome, lack of acceptance of non\u2010mechanical approaches) require careful evaluation by trained clinicians. Genetic predisposition to first onset TMDs and to chronification of symptoms has been identified for individuals with certain psychological traits, presence of comorbid conditions and certain abnormal clinical manifestations. Regarding iatrogenesis, sins of omission may influence the clinical picture, with the main ones being misdiagnosis and undertreatment. Joint repositioning strategies, occlusal modifications, abuse of oral appliances, use of diagnostic technologies, nocebo effect and complications with intracapsular treatments are the most frequent sins of commission that may contribute to chronification of TMDs. The patients who present with massive occlusal and jaw repositioning changes combined with persistent severe orofacial pain are not a rarity within TMD and orofacial pain canters; these patients are the most difficult ones to manage because of this horrific combination of negative factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The information presented in this paper will help clinicians to understand better why some individuals develop temporomandibular disorders, why some of them will progress to becoming chronic patients, and what the appropriate responses may be.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13180","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T13:32:46Z","timestamp":1620567166000},"page":"1077-1088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Transitioning to chronic temporomandibular disorder pain: A combination of patient vulnerabilities and iatrogenesis"],"prefix":"10.1111","volume":"48","author":[{"given":"Charles S.","family":"Greene","sequence":"first","affiliation":[{"name":"Department of Orthodontics University of Illinois at Chicago College of Dentistry Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4352-3085","authenticated-orcid":false,"given":"Daniele","family":"Manfredini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Technologies School of Dentistry University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"465","article-title":"Chronic musculoskeletal pain: nonpharmacologic, noninvasive treatments","volume":"102","author":"Flynn DM","year":"2020","journal-title":"Am Fam 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