{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:36:04Z","timestamp":1788820564985,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Occlusion can be viewed as the most sensitive susceptor of the central nervous system in the oro\u2010facial region. Its inalienable relationships to the temporomandibular joint, the muscles, the stomatognathic system and even the central nervous system are self\u2010evident. Almost all the dental treatments inevitably change the occlusion, potentially or actually, locally or extensively, and immediately or gradually.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to present a narrative literature on occlusal disharmony and chronic oro\u2010facial pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature reviews focusing on clinical studies about the relationship between occlusal disharmony and myofascial oro\u2010facial pain, and related preclinical studies about the animal models of, as well as the peripheral and central mechanisms underlying this condition related to, occlusal disharmony were used as starting point and guidelines to describe the topics mentioned. A search of the PubMed database was performed mainly with the following search terms: \u201cocclusion,\u201d \u201cocclusal interference,\u201d \u201cocclusal disharmony,\u201d \u201cocclusal change,\u201d \u201coro\u2010facial pain\u201d and \u201cmyofascial pain.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Relevant literature from the past 70 years until the present day was meticulously studied. The literature review together with three related characteristic clinical cases revealed an intimate association between occlusal disharmony and chronic oro\u2010facial pain, involving pathological changes, extending from the peripheral tissues to the central nervous system. The patients suffered from psychological distress, sleep disturbance and poor life quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Occlusal disharmony\u2013related oro\u2010facial pain is a clinical problem that deserves attention, although there are no universally accepted clinical protocols. The existing literature provides some constructive suggestions, but further research is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13236","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T13:08:55Z","timestamp":1627823335000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Occlusal disharmony and chronic oro\u2010facial pain: from clinical observation to animal study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-1480","authenticated-orcid":false,"given":"Ye","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Center for Oral and Jaw Functional Diagnosis, Treatment and Research Peking University School and Hospital of Stomatology Beijing China"},{"name":"Center for TMD &amp; Orofacial Pain Peking University School and Hospital of Stomatology Beijing China"},{"name":"National Clinical Research Center for Oral Diseases National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,14]]},"reference":[{"issue":"6","key":"e_1_2_5_2_1","first-page":"378","article-title":"Diagnosis and treatment of temporomandibular disorders","volume":"91","author":"Gauer RL","year":"2015","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2004.01439.x"},{"issue":"2","key":"e_1_2_5_4_1","first-page":"143","article-title":"Prevalence of signs and symptoms of temporomandibular disorders in an urban and rural German population: results of a population\u2010based Study of Health in Pomerania","volume":"35","author":"Gesch D","year":"2004","journal-title":"Quintessence Int"},{"issue":"3","key":"e_1_2_5_5_1","first-page":"270","article-title":"Symptoms of temporomandibular disorders in the population: an epidemiological study","volume":"24","author":"Goncalves DA","year":"2010","journal-title":"J Orofac Pain"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416686302"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2016.1191086"},{"issue":"2","key":"e_1_2_5_8_1","first-page":"144","article-title":"Prevalence of temporomandibular pain and subsequent dental treatment in Swedish adolescents","volume":"19","author":"Nilsson IM","year":"2005","journal-title":"J Orofac Pain"},{"key":"e_1_2_5_9_1","article-title":"Subtypes of acute and chronic temporomandibular disorders: Their relation to psychological and sleep impairments","author":"Cao Y","year":"2020","journal-title":"Oral Dis"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.01.063"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03740-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001435"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419893823"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01790.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2007.12.003"},{"issue":"5","key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.prosdent.2016.12.001","article-title":"The Glossary of Prosthodontic Terms: Ninth Edition","volume":"117","year":"2017","journal-title":"J Prosthet Dent"},{"issue":"8","key":"e_1_2_5_17_1","first-page":"662","article-title":"Changes in understanding of painful temporomandibular disorders: the history of a transformation","volume":"50","author":"Skarmeta NP","year":"2019","journal-title":"Quintessence Int"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(99)70012-0"},{"issue":"4","key":"e_1_2_5_19_1","first-page":"265","article-title":"The role of functional occlusal relationships in temporomandibular disorders: a review","volume":"5","author":"Seligman DA","year":"1991","journal-title":"J Craniomandib Disord"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90096-2"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163502760147981"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350500419867"},{"issue":"4","key":"e_1_2_5_23_1","first-page":"227","article-title":"Association of occlusal variables among refined TM patient diagnostic groups","volume":"3","author":"Seligman DA","year":"1989","journal-title":"J Craniomandib Disord"},{"key":"e_1_2_5_24_1","volume-title":"Manual of temporomandibular disorders","author":"Wright EF","year":"2010"},{"issue":"6","key":"e_1_2_5_25_1","first-page":"373","article-title":"Electrical pain thresholds of face and finger in patients with chronic masticatory muscle pain","volume":"44","author":"Cao Y","year":"2009","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2018.1495304"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e328014a871"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.758"},{"issue":"1","key":"e_1_2_5_29_1","first-page":"25","article-title":"Changes of productions of energy metabolism in masseter of rats induced by occlusal interference","volume":"49","author":"Xu XX","year":"2017","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516657070"},{"issue":"10","key":"e_1_2_5_31_1","first-page":"596","article-title":"Characteristics of experimental occlusal interference\u2010induced masticatory mechanical hyperalgesia of rats","volume":"49","author":"Li X","year":"2014","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2007.01750.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2012.02300.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9416(76)90319-5"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12309"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12950"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2012.0325"},{"issue":"1","key":"e_1_2_5_38_1","first-page":"38","article-title":"Phantom bite: a survey of US orthodontists","volume":"12","author":"Ligas BB","year":"2011","journal-title":"Orthodontics (Chic.)"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.07.058"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00465-2"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00489-4"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.02.022"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-40"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.006"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345540330040701"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.11.012"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.104588"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12112"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1964.35.6.470"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2001.00568.x"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(83)90216-0"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0409-3"},{"issue":"6","key":"e_1_2_5_53_1","first-page":"588","article-title":"Central mechanisms of masticatory muscle pain induced by occlusal interference","volume":"25","author":"Yu YF","year":"2007","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.04.029"},{"issue":"1","key":"e_1_2_5_55_1","first-page":"51","article-title":"Characteristics of orofacial operant test for orofacial pain sensitivity caused by occlusal interference in rats","volume":"52","author":"Bai SS","year":"2020","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"e_1_2_5_56_1","first-page":"51","article-title":"Influence of the occlusal interference time on masticatory muscle mechanical hyperalgesia in rats","volume":"48","author":"Liu CR","year":"2016","journal-title":"J Peking Univ Health Sci"},{"issue":"10","key":"e_1_2_5_57_1","first-page":"596","article-title":"Characteristics of experimental occlusal interference\u2010induced masticatory mechanical hyperalgesia of rats","volume":"49","author":"Li X","year":"2014","journal-title":"Chin J Stomatol"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/08990220500420475"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.6.2868"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0176-07.2007"},{"issue":"1","key":"e_1_2_5_61_1","first-page":"50","article-title":"Experimental occlusal interference induces the expression of protein gene products and substance P in masseter muscles of rats","volume":"42","author":"Cao Y","year":"2010","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100412"},{"issue":"3","key":"e_1_2_5_63_1","first-page":"191","article-title":"The association of temporomandibular disorder pain with history of head and neck injury in adolescents","volume":"20","author":"Fischer DJ","year":"2006","journal-title":"J Orofac Pain"},{"issue":"4","key":"e_1_2_5_64_1","first-page":"238","article-title":"The neural basis of temporomandibular joint and masticatory muscle pain","volume":"13","author":"Sessle BJ","year":"1999","journal-title":"J Orofac Pain"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90027-M"},{"issue":"5","key":"e_1_2_5_66_1","first-page":"421","article-title":"Expression of PN3 and NaN in trigeminal ganglion during occlusal trauma in rat","volume":"39","author":"Zhu ML","year":"2004","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"issue":"5","key":"e_1_2_5_67_1","first-page":"418","article-title":"The expression of PPTA and c\u2010fos mRNA in dog caudal spinal trigeminal nucleus induced by traumatic occlusion","volume":"39","author":"Dong Y","year":"2004","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.02.005"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519827590"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13211"},{"key":"e_1_2_5_71_1","volume-title":"The Mechanisms of Rostral Ventromedial Medulla Modulating Different Outcomes of Experimental Occlusal Interference\u2010induced Orofacial Hyperalgesia in rats","author":"Mo S\u2010Y","year":"2021"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.02.006"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joor.13236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:26:03Z","timestamp":1693221963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.13236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,14]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/joor.13236"],"URL":"https:\/\/doi.org\/10.1111\/joor.13236","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.13236\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13236\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13236\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13236\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13236\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13236\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,14]]},"assertion":[{"value":"2021-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}