{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:05Z","timestamp":1772160725532,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870788"],"award-info":[{"award-number":["81870788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200801"],"award-info":[{"award-number":["81200801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, there is a lack of effective therapy for chronic pain. Increasing evidence has shown that chemokines and their correlative receptors involved in the neuron\u2013glial cell cross\u2010talk could contribute to the pathogenesis of neuropathic pain. Our previous studies suggested that CXCR3 expression was elevated in the spinal dorsal horn after nerve injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In this study, we aimed to explore the role of CXCR3 signalling in chronic pain modulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Reverse transcription quantitative PCR and Western blotting were used to measure the expression of CXCR3 and its ligands in the spinal cord following chronic constriction injury (CCI) of the sciatic nerve. Cxcr3 \u2010knockout mice were used to observe the effect of the receptor on pain\u2010related behaviour and microglial activation. Immunohistochemistry was used to investigate the expression of two activation markers for spinal microglia, Iba\u20101 and phosphorylated\u2010p38 (p\u2010p38) in these mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The expression of CXCR3 and its ligand CXCL11 was upregulated in the lumbar dorsal horn of the spinal cord in CCI models. In Cxcr3 \u2010knockout mice, CCI\u2010induced tactile allodynia and thermal hyperalgesia were observed to be alleviated during the early stage of pain processing. Meanwhile, the expression of the glial activation markers, namely, Iba\u20101 and p\u2010p38, was decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results demonstrate that CXCR3 could be a key modulator involved in pain modulation of the spinal cord; therefore, CXCR3\u2010related signalling pathways could be potential targets for the treatment of intractable pathological pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13262","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T17:33:32Z","timestamp":1632764012000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CXCR3 signalling partially contributes to the pathogenesis of neuropathic pain in male rodents"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4140-3802","authenticated-orcid":false,"given":"Kai","family":"Li","sequence":"first","affiliation":[{"name":"Center for TMD &amp; Orofacial Pain Peking University School &amp; Hospital of Stomatology Beijing China"},{"name":"Department of General Dentistry II Peking University School &amp; Hospital of Stomatology Beijing China"},{"name":"Central Laboratory Peking University School &amp; Hospital of Stomatology Beijing China"},{"name":"National Center of Stomatology &amp; National Clinical Research Center for Oral Diseases Beijing China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Hui","family":"Tan","sequence":"additional","affiliation":[{"name":"Center for TMD &amp; Orofacial Pain Peking University School &amp; Hospital of Stomatology Beijing 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