{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:13:26Z","timestamp":1791335606379,"version":"4.3.1"},"reference-count":182,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171000"],"award-info":[{"award-number":["82171000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Orthodontic treatment is the main treatment approach for malocclusion. Orthodontic pain is an inevitable undesirable adverse reaction during orthodontic treatment. It is reported orthodontic pain has become one of the most common reason that patients withdraw from orthodontic treatment. Therefore, understanding the underlying mechanism and finding treatment of orthodontic pain are in urgent need.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This article aims to sort out the mechanisms and treatments of orthodontic pain, hoping to provide some ideas for future orthodontic pain relief.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials<\/jats:title>\n                    <jats:p>Tooth movement will cause local inflammation. Certain inflammatory factors and cytokines stimulating the trigeminal nerve and further generating pain perception, as well as drugs and molecular targeted therapy blocking nerve conduction pathways, will be reviewed in this article.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We review and summaries current studies related to molecular mechanisms and treatment approaches in orthodontic pain control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Orthodontics pain related influencing factors and molecular mechanisms has been introduced. Commonly used clinical methods in orthodontic pain control has been evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>With the clarification of more molecular mechanisms, the direction of orthodontic pain treatment will shift to targeted drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13263","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T15:04:33Z","timestamp":1632927873000},"page":"125-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Molecular mechanism in trigeminal nerve and treatment methods related to orthodontic pain"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-9687","authenticated-orcid":false,"given":"Ziwei","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzi","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Lai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","first-page":"Cd007859","article-title":"Initial arch wires used in orthodontic treatment with fixed appliances","volume":"2018","author":"Wang Y","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jos.JOS_87_18"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1993.tb00715.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13557"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12314"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2019.05.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1179\/bjo.12.3.133"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(98)70201-X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjz068"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01245-w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2015.06.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3699.971"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-79090-7_13"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-016-0013-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2319\/121308-632R.1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9457-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjaa037"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2583-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2002.1114"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-2-30"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.211878"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2016.24"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2017.01.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160266497"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6683161"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S143734"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2018.08.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf022"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2011.00012"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12293"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12542"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.03.010"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/951920"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2625-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510377094"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2015.12.005"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2005.00057.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.30"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201720160865"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03524.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000527"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720160150"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0003-1"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12052"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520950296"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3529"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.08.006"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.11.023"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.09.032"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46663"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.12"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3318"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjv082"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.06.023"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0448-y"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01353"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089137"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2008.11.005"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0044-3"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12158"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01040"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00524.2018"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12990-015-0072-8"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0526-0"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000498"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01851.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.088997"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16519"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1815191"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.12.014"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2021.105170"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2014_18"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.361139"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113320"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0804-4"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.08.021"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65618-5"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww038"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5616"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.12.016"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1739-y"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-020-00282-1"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02284-2"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00108-z"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193270"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.612697"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat9897"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.604033"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.094"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.035"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00522-z"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09055-7"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910213116"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.02.015"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113834"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa6769"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07369"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-7"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092266"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517702342"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13251"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13250"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat9892"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctm.2016.10.002"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.07.014"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046379"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.03.002"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-024-1057-0_5"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.11.014"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2018.11.010"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.01.062"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.090233"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.63"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.04.033"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.33.225"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2011.01122.x"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134630"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2009.01143.x"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155206"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417720216"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185543"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00170"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279203"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0236-19.2019"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.2"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2019.1615824"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1782719"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517741253"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1154-0"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017360"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0552-2"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2009.01605.x"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12315"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-017-0150-1"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.06.006"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.049"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S113436"},{"issue":"1","key":"e_1_2_9_140_1","first-page":"53","article-title":"Functional clustering of the human inferior parietal lobule by whole\u2010brain connectivity mapping of resting\u2010state functional magnetic resonance imaging signals","volume":"4","author":"Zhang S","year":"2014","journal-title":"Brain Connectivity"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.03.039"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4139404"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906186106"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1037\/bul0000096"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.589125"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjy081"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-020-00254-2"},{"issue":"1","key":"e_1_2_9_148_1","first-page":"239","article-title":"Substance P expression in the gingival tissue after upper third molar extraction: effect of ketoprofen, a preliminary study","volume":"31","author":"Abbate GM","year":"2017","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-016-0156-7"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjx013"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1743-4"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8560652"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-018-0023-0"},{"issue":"12","key":"e_1_2_9_154_1","first-page":"Cd010263","article-title":"Non\u2010pharmacological interventions for alleviating pain during orthodontic treatment","volume":"12","author":"Fleming PS","year":"2016","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02923-0"},{"issue":"11","key":"e_1_2_9_156_1","first-page":"Zc23","article-title":"Evaluation of low level laser therapy on pain perception following orthodontic elastomeric separation: A randomized controlled trial","volume":"10","author":"Almallah MM","year":"2016","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.22009"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.04.029"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.20-0437"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000609"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.11.004"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.104"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01041"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.11.007"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12258"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2018.04.011"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12144"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3516"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.07.017"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01555-8"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-016-9521-8"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416653233"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13379"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.197"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13081"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000227"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709038"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705848"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0944-0"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.007"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.04.147"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.12.009"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn9000186"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joor.13263","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:25:50Z","timestamp":1693221950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.13263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":182,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/joor.13263"],"URL":"https:\/\/doi.org\/10.1111\/joor.13263","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.13263\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13263\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13263\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13263\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13263\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13263\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]},"assertion":[{"value":"2021-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}