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Malocclusion due to some craniofacial anatomical characteristics may be associated with SDB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this paper is to ascertain whether SDB is associated with malocclusion in children\/adolescents, aged 6\u201315\u00a0years compared to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospero ID: CRD42021232103. A systematic electronic literature search following PRISMA was performed in PubMed, Embase and Cochrane Library. Inclusion criteria were as follows: Healthy children\/adolescents aged 6\u201315\u00a0years with malocclusion undergoing polysomnography (PSG) or polygraphy (PG) and\/or sleep questionnaire and orthodontic screening; compared to a healthy age\u2010matched control group with neutral or minor deviation in the occlusion without requirement for orthodontic treatment; publications in English, Danish, Norwegian or Swedish published until 23\u00a0March 2021. JBI Critical Appraisal Tools and GRADE were used to evaluate the risk of bias and level of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search resulted in 1996 records, 610 duplicates were removed, 1386 records were screened, and 1322 records were excluded. Sixty\u2010four studies were selected for full\u2010text reading, and four publications fulfilled the inclusion criteria. The included studies had moderate risk of bias, and the quality of evidence was low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No firm conclusion can be drawn regarding an association between specific malocclusion traits and SDB. Thus, the studies found no association between molar relationship and crowding and SDB symptoms in children. It may be recommended that future studies include objective PSG or PG in diagnosis of SDB and compare groups of children with skeletal malocclusion and controls with neutral malocclusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13282","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T13:26:22Z","timestamp":1636982782000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sleep\u2010disordered breathing and malocclusion in children and adolescents\u2014a systematic review"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1221-8704","authenticated-orcid":false,"given":"Camilla","family":"Hansen","sequence":"first","affiliation":[{"name":"Section of Orthodontics Department of Odontology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen 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