{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:49:39Z","timestamp":1775044179209,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular joint osteoarthritis (TMJ\u2010OA) causes severe symptoms such as chewing difficulties, acute pain and even maxillofacial deformity. However, there is hardly any effective disease\u2010curing strategy because of uncertainty in aetiology. Animal model is an excellent tool to investigate the mechanism, prevention and treatment on diseases. Currently, although several TMJ\u2010OA animal models have been established, there are almost no comparative studies on different models, which poses a great challenge for selecting suitable models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare three TMJ\u2010OA induction methods and assess their applicability considering pathological changes in the cartilage, subchondral bone, osteoclasts, and synovium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Murine models were employed and followed for 3 and 6\u00a0weeks after experimental procedures (surgery, injection, crossbite). The TMJ changes were evaluated by Safranin\u2010O\/Fast green staining, immunofluorescence staining, micro\u2010CT, TRAP staining, and HE staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the Surgery group, a pronounced drop in bone volume fraction was observed. In the Injection group, chondrocytes were mostly disordered or arranged in clusters and a substantial increase in the OARSI score and osteoclasts was found. The OARSI score and osteoclasts also increased significantly in the Crossbite group, although to a lower extent compared with injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Osteoarthritis\u2010like changes were observed in all models. Concerning the applicability of the different induction methods, surgery might be an important resource for the assessment of post\u2010traumatic TMJ\u2010OA and subchondral bone changes in early stages. Injection induces a severe end\u2010stage osteoarthritis in a short time and provides model basis for advanced TMJ\u2010OA. Crossbite might be more reasonable model to explore the pathogenesis mechanism of temporomandibular arthritis due to occlusal disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13300","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T11:47:39Z","timestamp":1640173659000},"page":"430-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison and applicability of three induction methods of temporomandibular joint osteoarthritis in murine models"],"prefix":"10.1111","volume":"49","author":[{"given":"Wenxiu","family":"Yuan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Lab for Aging Research State Key Laboratory of Biotherapy and National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yange","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Lab for Aging Research State Key Laboratory of Biotherapy and National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueman","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Lab for Aging Research State Key Laboratory of Biotherapy and National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingcheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"},{"name":"Lab for Aging Research State Key Laboratory of Biotherapy and National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-6295","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Lab for Aging Research State Key Laboratory of Biotherapy and National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0802472"},{"key":"e_1_2_10_3_1","first-page":"378","article-title":"Diagnosis and treatment of temporomandibular disorders","volume":"91","author":"Gauer RL","year":"2015","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801236"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb6683"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.02.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(96)70081-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700406"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00498-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2019.10.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(89)80041-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.656153"},{"key":"e_1_2_10_13_1","first-page":"1107","article-title":"Site specific inhibition of cartilage proteoglycan synthesis in the murine knee joint. 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