{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:12:28Z","timestamp":1784805148888,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Unilateral posterior crossbite, one of the most frequent malocclusions, is often associated with functional lateral shift of the mandible. Although the effects of functional lateral shift on the mandible and temporomandibular joint have been examined in various animal experiments, cranial and maxillary changes have received less attention.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of this study was to investigate the effects of functional lateral shift on the craniofacial complex in growing rats.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighty 5\u2010week\u2010old male Sprague\u2013Dawley rats were randomly divided into an experimental group (\n n<\/jats:italic>\n \u00a0=\u00a040), which received an oblique guide appliance that shifted the mandible to the left during closure, and a control group (\n n<\/jats:italic>\n \u00a0=\u00a040). The rats were scanned by cone\u2010beam computed tomography at 3\u2009days and 1, 2, 4 and 8\u2009weeks. The dimensions of the mandibular bone, condyle, maxilla and cranium were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The mandibles of rats in the experimental group were smaller than those of the rats in the control group and were asymmetrical. The condyles of the rats in the experimental group were thinner than those of the control rats. The condylar length on the ipsilateral side was shorter and wider than that on the contralateral side from 4 to 8\u2009weeks. No significant differences in cranial length or height were observed between the experimental and control groups. The height of the upper first molar and alveolar bone on the contralateral side was significantly smaller than that on the ipsilateral side and in the controls from 4 to 8\u2009weeks.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Functional shift in the mandible produces morphological asymmetries in the mandible and maxillary region and may cause bilateral condylar degenerative changes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/joor.13341","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T11:50:30Z","timestamp":1652874630000},"page":"915-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of functional mandibular lateral shift on craniofacial growth and development in growing rats"],"prefix":"10.1111","volume":"49","author":[{"given":"Yuchun","family":"Zou","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Orthodontics Department, School and Hospital of Stomatology Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Orthodontics Department, School and Hospital of Stomatology Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Cai","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Orthodontics Department, School and Hospital of Stomatology Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqi","family":"Xie","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Orthodontics Department, School and Hospital of Stomatology Fujian Medical University Fuzhou 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