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Statistical analyses included Fisher's Exact Test, multiple logistic and linear regression models adjusted for age, gender and Body Mass Index (BMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Single symptoms and signs of TMD occurred significantly more often in hEDS (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002;<jats:italic>p<\/jats:italic>\u00a0=\u2009.001;<jats:italic>p<\/jats:italic>\u00a0=\u2009.003;<jats:italic>p<\/jats:italic>\u00a0=\u2009&lt;.0001;<jats:italic>p<\/jats:italic>\u00a0=\u2009.012) and maximum mouth opening was significantly smaller in hEDS compared to controls (<jats:italic>p<\/jats:italic>\u00a0=\u2009&lt;.0001). The DC\/TMD diagnosis myalgia, myofascial pain with referral, arthralgia, headache attributed to TMD, disc displacement disorders and degenerative joint disease occurred significantly more often in hEDS compared to controls (<jats:italic>p<\/jats:italic>\u00a0=\u2009.000;<jats:italic>p<\/jats:italic>\u00a0=\u2009.008;<jats:italic>p<\/jats:italic>\u00a0=\u2009.003;<jats:italic>p<\/jats:italic>\u00a0=\u2009.000;<jats:italic>p<\/jats:italic>\u00a0=\u2009&lt;.0001;<jats:italic>p<\/jats:italic>\u00a0=\u2009.010, respectively). No significant differences were found in bite force and in teeth in occlusal contact between the groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u2009.05). On CBCT of the TMJs, subcortical sclerosis occurred significantly more often in hEDS compared to controls (<jats:italic>p<\/jats:italic>\u00a0=\u2009.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Symptoms and signs of TMD and osseous changes of the TMJs occurred significantly more often in hEDS. Bite force and teeth in occlusal contact were comparable to controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13348","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T08:18:17Z","timestamp":1655108297000},"page":"872-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Temporomandibular disorders, bite force and osseous changes of the temporomandibular joints in patients with hypermobile Ehlers\u2010Danlos syndrome compared to a healthy control group"],"prefix":"10.1111","volume":"49","author":[{"given":"Karen","family":"Bech","sequence":"first","affiliation":[{"name":"Section of Orthodontics, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikke Maria","family":"Fogh","sequence":"additional","affiliation":[{"name":"Section of Orthodontics, 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