{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:37:58Z","timestamp":1792805878424,"version":"4.5.0"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302892\/2019\u20102"],"award-info":[{"award-number":["302892\/2019\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous evidence indicates significant association between genetic polymorphisms and phenotypes related to pain sensitivity in patients with temporomandibular disorders (TMD). Despite the important advances in cataloguing diverse factors such as sleep disorders, anxiety and depression, the interrelated mechanisms of painful TMD aetiopathogenesis still need investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This case\u2013control study aimed to evaluate the influence of genetic polymorphisms (rs6296, rs6295, rs1799971, rs4680, rs4633, rs4818) and psychosocial factors on the mechanical pain sensitivity and endogenous pain modulation in women with painful TMD and asymptomatic controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated six independent variables: anxiety levels, depression, stress, sleep quality, pain catastrophising and genetic polymorphisms, and four dependent variables: mechanical pain threshold (MPT), pressure pain threshold (PPT), wind\u2010up ratio (WUR) and conditioned pain modulation (CPM) collected at masseter (trigeminal) and hand (spinal) areas in a sample of 95 painful TMD patients and 85 controls. A regression model was used to test the possible effect of the independent variables on dependent variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The regression model was significant for MPT (\n                      <jats:italic>F<\/jats:italic>\n                      <jats:sub>11,168<\/jats:sub>\n                      \u00a0=\u00a09.772;\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a0.390). Painful TMD diagnoses and sleep quality were associated with trigeminal MPT (\n                      <jats:italic>B<\/jats:italic>\n                      coefficient\u00a0=\u00a0\u2212.499; and\n                      <jats:italic>B<\/jats:italic>\n                      coefficient\u00a0=\u00a0\u2212.211, respectively). WUR was associated with rs6295 and rs6746030, respectively, for the spinal and the trigeminal area.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Genetic polymorphisms had a slight contribution to endogenous pain modulation as indicated by the significant association with WUR but did not contribute to mechanical pain sensitivity. On the other hand, the presence of painful TMD and the sleep quality contributed significantly to mechanical pain sensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13384","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T04:05:15Z","timestamp":1666757115000},"page":"39-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of genetic polymorphisms on mechanical pain sensitivity and endogenous pain modulation of trigeminal and spinal areas"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-3626","authenticated-orcid":false,"given":"Fl\u00e1via Fonseca Carvalho","family":"Soares","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry, University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyna Mara Ara\u00fajo Oliveira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Bauru School of Dentistry, University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda\u00a0Ayla","family":"Raimundini","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry, University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Jos\u00e9","family":"Dion\u00edsio","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry, University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Ferreira","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bauru School of Dentistry, University of S\u00e3o Paulo  Bauru 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