{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:51:16Z","timestamp":1787169076574,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160180"],"award-info":[{"award-number":["82160180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Burning mouth syndrome (BMS) is characterised by persisting burning pain of the oral mucosa, and its etiopathogenesis remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our study aimed to detect the expression of miRNA\u2010206 in the blood and clarify the relationship among miRNA\u2010206, pain, anxiety and depression of BMS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty patients with BMS and 30 healthy individuals were enrolled in the experimental and control groups, respectively. Data on medical history and clinical oral examination for all participants were collected. Simultaneously, scores of Visual Analogous Scale (VAS), Self\u2010rating Anxiety Scale (SAS) and Self\u2010rating Depression Scale (SDS) were administered. The expression level of miRNA\u2010206 in plasma were determined by RT\u2010(q)PCR. Finally, the relationship of miRNA\u2010206 expression with the VAS score, SAS score, and SDS score was analysed. Chi\u2010square test and t\u2010test were used for statistical analysis of the data, and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The majority of the patients with BMS identified the tongue as the main pain area, and showed dry mouth and poor sleep quality. The SAS and SDS scores of patients with BMS were higher than those of healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) and were positively correlated with VAS pain score. In addition, miRNA\u2010206 expression was higher in patients with BMS than in healthy individuals (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05), and was positively correlated with the VAS and SDS scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with BMS suffer from pain and tend to be more anxious and depressed than healthy controls. miRNA\u2010206 expression in the peripheral blood of patients with BMS is positively correlated with pain and depression, which may be involved in the pathogenesis of BMS.<\/jats:p>\n                  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