{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:49:54Z","timestamp":1784825394913,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["RC202107"],"award-info":[{"award-number":["RC202107"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["RC202106"],"award-info":[{"award-number":["RC202106"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effect of functional orthopaedic treatment for mandibular deficiency relies on mandibular advancement (MA)\u2010induced condylar new bone formation. However, this is not easy to achieve, especially in non\u2010growing patients. Therefore, how to obtain reliable MA\u2010induced condylar osteogenesis is a subject much worthy of study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether deferoxamine mesylate (DFM) enhances MA\u2010induced condylar osteogenesis in middle\u2010aged mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty 30\u2010week\u2010old male C57BL\/6J mice were randomly divided into 4 groups: the control (Ctrl), DFM, MA\u2009+\u2009Ctrl and MA\u2009+\u2009DFM groups. After a 4\u2010week experimental period, femurs, tibias and condyles were collected for morphological, micro\u2010computed tomography and histological evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For long bones, DFM reversed osteoporosis in middle\u2010aged mice by promoting H\u2010type angiogenesis. For mandibular condyles, MA promoted condylar osteogenesis in middle\u2010aged mice, thereby allowing the mandible to achieve a stable protruding position. In addition, DFM enhanced the volume and quality of MA\u2010induced condylar new bone formation. Furthermore, histological analysis revealed that DFM enhanced MA\u2010induced condylar subchondral ossification. Mechanistically, it was confirmed that DFM increased the number of H\u2010type vessels and their coupled Osterix\n                      <jats:sup>+<\/jats:sup>\n                      osteoprogenitors by upregulating the hypoxia\u2010inducible factor (HIF)\u20101\u03b1 signalling pathway, thereby enhancing MA\u2010induced condylar osteogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Applying DFM to enhance MA\u2010induced condylar osteogenesis through H\u2010type angiogenesis is expected to be an effective strategy to achieve favourable functional orthopaedic treatment effectiveness in non\u2010growing patients.<\/jats:p>\n                  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