{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:24:22Z","timestamp":1790061862382,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013116","name":"Merz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies concerning the effect of botulinum toxin in masseter muscle have mainly reported effects observed through inspection of facial features or differences in pain levels. One systematic review of studies utilizing objective measurements reported that long\u2010term muscular effect of botulinum neurotoxin injections into masseter muscle was inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the duration of reduced maximal voluntary bite force (MVBF) after botulinum toxin intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The intervention group was comprised of individuals seeking aesthetic treatment for masseter reduction (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200920), the reference group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200912) comprised of individuals with no intervention. Intervention through 25\u2009units of Xeomin\u00ae (Merz Pharma GmbH &amp; Co KGaA, Frankfurt am Main, Germany) botulinum neurotoxin type A injected into the masseter muscles bilaterally (totalling 50\u2009units). A reference group did not receive any intervention. MVBF was measured in Newtons using a strain gauge meter at the incisors and first molars. MVBF was measured at baseline, at 4\u2009weeks, 3\u2009months, 6\u2009months, and after 1\u2009year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups were similar in terms of bite force, sex and age at baseline. MVBF remained similar compared to baseline in the reference group. At 3\u2009months, a significant reduction at all measurement points was observed in the intervention group; at 6\u2009months, this reduction was no longer significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single intervention of 50\u2009units of botulinum neurotoxin results in a reversible MVBF reduction of at least 3\u00a0months, although a visually discernable reduction may be more long\u2010lasting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13434","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T01:43:33Z","timestamp":1677030213000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Duration of bite force reduction following a single injection of botulinum toxin in the masseter muscle bilaterally: A one\u2010year non\u2010randomized trial"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1451-7505","authenticated-orcid":false,"given":"Martin","family":"\u00c5gren","sequence":"first","affiliation":[{"name":"Department of Odontology, Faculty of Medicine Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Prosthodontic Specialist Clinic Region V\u00e4sterbotten  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2744-1909","authenticated-orcid":false,"given":"Yanisorn","family":"Nanchaipruek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phumithep","family":"Phumariyapong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 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