{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:33:20Z","timestamp":1787884400149,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Over the past few years, researchers have investigated whether varying menstrual statuses and oestrogen levels could affect the likelihood of temporomandibular disorders (TMDs), with conflicting results. While some studies suggest a potential link between increased oestrogen levels and higher TMD risk, others have found no correlation. It is worth noting that oestrogen levels can impact the structure and function of the temporomandibular joint (TMJ). In the light of these findings, our study seeks to investigate the prevalence of TMDs among pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched in PubMed, Web of Science and Lilacs for articles published from the inception until 20 January 2023. We applied the Population, Exposure, Comparator and Outcomes (PECO) model to assess the document eligibility: (P) Participants: female human subjects. (E) Exposure: pregnancy. (C) Comparison: pregnant women compared to non\u2010pregnant women in the childbearing age. (O) Outcome: TMDs diagnosis. Only study providing data about the prevalence in both group (pregnant and non\u2010pregnant) were included. We set the following exclusion criteria: (1) diagnosis of rheumatic diseases or chronic inflammatory disorders (e.g. rheumatoid arthritis, juvenile, idiopathic arthritis, psoriatic arthritis); (2) diagnosis of fibromyalgia; (3) congenital abnormality or neoplastic conditions in the TMJ region; (4) studies including subjects undergoing arthrocentesis or intra\u2010articular infiltrations; (5) studies including local pressure pain assessment; (6) studies including women in menopause in the control group (7) cross\u2010over study design; (8) language different from English; (9) full\u2010 text unavailability (i.e. posters and conference abstracts); (10) studies involving animals; (11) review (topical or systematic) article; (12) case reports\/series; (13) studies evaluating TMDs prevalence in subjects not pregnant. The software Review Manager version 5.2.8 (Cochrane Collaboration) was used to perform the pooled analysis. We measured the risk ratio (RR) between the two groups (pregnant and non\u2010pregnant).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The included subjects in this review were 440. Among them, 244 were pregnant while the remaining 196 were age matched non\u2010pregnant women. Among those pregnant 102 presented sign\/symptoms of TMD or TMD diagnosis (41.8%) whereas 80 of those not pregnant were diagnosed with (40.8%). The overall effect showed that there was no difference in TMD prevalence between pregnant and non\u2010pregnant women in childbearing age (RR 1.12; 95% CI: 0.65\u20131.93), suggesting that pregnant is neither a risk factor nor a protective factor for TMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, we did not find an association between TMD and pregnancy, neither positive nor negative. Further studies on larger samples are needed to clarify our results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13458","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T09:22:11Z","timestamp":1680772931000},"page":"627-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Prevalence of temporomandibular disorders (<scp>TMD<\/scp>) in pregnancy: A systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-1272","authenticated-orcid":false,"given":"Giuseppe","family":"Minervini","sequence":"first","affiliation":[{"name":"Multidisciplinary Department of Medical\u2010Surgical and Odontostomatological Specialties University of Campania \u201cLuigi Vanvitelli\u201d  Naples 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