{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:46:24Z","timestamp":1781837184940,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Condylar hyperplasia (CH) is a rare condition characterised by excessive unilateral growth of the mandibular condyle after cessation of growth on the contralateral side causing facial asymmetry, being more prevalent in the second and third decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine the utility of vascular endothelial growth factor (VEGF\u2010A) as a diagnostic and prognostic factor in condylar hyperplasia, and to determine its potential viability as a therapeutic target.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2013control study, where 17 mandibular condyles specimens were collected from 17 patients treated for active mandibular condyle hyperplasia and three unaffected human mandibular condyles from cadavers will serve as the control group. The samples were immunostained with VEGF\u2010A antibody and evaluated on both quantity and intensity of staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VEGF\u2010A was qualitatively found to be greatly upregulated in patients with condylar hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VEGF\u2010A was qualitatively found to be upregulated in patients affected by CH, validating VEGF\u2010A as a potential diagnostic, prognostic and therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13487","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T15:00:44Z","timestamp":1683126044000},"page":"845-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Mandibular condylar hyperplasia and its correlation with vascular endothelial growth factor"],"prefix":"10.1111","volume":"50","author":[{"given":"Luis Eduardo","family":"Almeida","sequence":"first","affiliation":[{"name":"Surgical Sciences Department, School of Dentistry Marquette University  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-9728","authenticated-orcid":false,"given":"Marco","family":"Cicci\u00f9","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Surgical and Biomedical Sciences Catania University  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Doetzer","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia Pontificia Universidade Catolica do Parana  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Beck","sequence":"additional","affiliation":[{"name":"Surgical Sciences Department, School of Dentistry Marquette University  Milwaukee Wisconsin 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