{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:10:42Z","timestamp":1792627842450,"version":"4.5.0"},"reference-count":83,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Candida albicans is linked to persistent endodontic lesions. However, the recognition receptor that identifies it is not explored previously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to (1) establish a zymosan\u2010induced model of apical periodontitis in mouse, (2) observe the expression of Dectin\u20101 and its possible relationship with toll\u2010like receptor (TLR) 2 and (3) observe relationship between Osteopontin (OPN) and inflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 138 Naval Medical Research Institute (NMRI) mice were randomly divided into; Experimental Group\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969 and Zymosan Group n\u2009=\u200969. Periapical periodontitis was developed in right maxillary molar. The animals were sacrificed at 7, 21 and 42\u2009days. Bone blocks containing the mesial root (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915 for qRT\u2010PCR,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945 for enzyme\u2010linked immune sorbent assay (ELISA)) were collected for mRNA expression and ELISA. While whole maxilla (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093 from each time interval) were used for histology and immunohistochemical analysis. One way analysis of variance (ANOVA) and Tuckey's posthoc was used for statistical analysis at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u2009.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TLR\u20102, Dectin\u20101 and TLR4\u2010positive cells was detected at all time intervals in both groups. A strong positive correlation was observed between TLR\u20102 and Dectin\u20101 in both lesions (regular\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009.680,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.015, zymosan (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009.861,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001)). A significant correlation was found between OPN and tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) in zymosan lesion (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009.827,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Immune cells of inflamed periapical tissue expressed Dectin\u20101 receptor in response to the microbial challenge from infected root canals and showed positive correlation with TLR\u20102 and OPN suggesting a possible receptor collaboration mediated by OPN. The expression of OPN and TNF\u2010\u03b1 showed positive correlation in response to fungal antigen, indicating a possible relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13528","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T23:32:09Z","timestamp":1685662329000},"page":"1043-1057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel experimental model to investigate fungal involvement shows expression of Dectin\u20101 in periapical lesion pathogenesis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-0308","authenticated-orcid":false,"given":"Arshad","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry, Dow Dental College Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Roome","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section Molecular Pathology Dow International Medical College  Karachi Pakistan"},{"name":"Dow Institute for Advanced Biological and Animal Research Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Wahid","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dow International Medical College Dow University of Health Sciences  Karachi Pakistan"},{"name":"Dow Research Institute of Biotechnology and Biomedical Sciences Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia Akbar","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Dow Dental College Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javeria Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Dow Dental College Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Kiyani","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Diagnosis, Islamic International dental College Riphah International University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Neha Ahmed","family":"Jilani","sequence":"additional","affiliation":[{"name":"Dow Institute for Advanced Biological and Animal Research Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Cohen's Pathways of the Pulp\u2010E\u2010Book","author":"Berman LH","year":"2020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.01.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.10.036"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02861-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.1997.00058.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.01.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2021.11.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03702-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.02.016"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302x.2001.016002100.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01648"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04732-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02621-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5454.860"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4223-4230.1999"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3228"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002735"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493219"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03159.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909870116"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"e_1_2_11_23_1","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Institute for Laboratory Animal Research NRC","year":"1986"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.09.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3791\/54973"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01998966"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23383"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3885-3893.2003"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-134"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790010401"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.69.2.744-750.2001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.122641"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2017-0512"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12204"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.03.017"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2022.02.002"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00754.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-9969(98)00094-6"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13534"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.10.007"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.9.3781-3787.1997"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517741261"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.68.8.4681-4687.2000"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.7.3626"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.11.1.106-110.2004"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000142249.08135.e9"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.4.3342"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(79)90062-6"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021787"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2005.00017.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000669"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.06.008"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0324-7"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00431-08"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2007.00355.x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13169"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0099-2399(99)80268-4"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00227.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.40.9.3223-3231.2002"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00214.x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(95)00042-9"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.53.1.149-153.1986"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.129535"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.04.007"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.10.022"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190469"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46212-0"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2006.00270.x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.106576"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.118620"},{"key":"e_1_2_11_71_1","volume-title":"Bacteriological Studies of Necrotic Dental Pulps","author":"Sundqvist G","year":"1976"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.1992.tb00584.x"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46835-0"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13457"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01893.x"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16678.1"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.10.031"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.004"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0010042"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.73.3.1553-1560.2005"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302x.1997.tb00619.x"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-5890(02)00210-9"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119080343"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.812148"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:32:59Z","timestamp":1696296779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.13528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":83,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/joor.13528"],"URL":"https:\/\/doi.org\/10.1111\/joor.13528","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.13528\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13528\/v1\/review2","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]},"assertion":[{"value":"2022-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}