{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:52Z","timestamp":1787015692164,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bruxism is a parafunctional activity characterised by grinding or clenching of teeth and is a common oral health concern in individuals with down syndrome (DS). Understanding the prevalence of bruxism in this population is crucial for developing effective management strategies. This systematic review and meta\u2010analysis is aimed to investigate the prevalence of bruxism among individuals with DS and explore its association with other oral health issues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive search was conducted across multiple electronic databases to identify relevant studies. Cross\u2010sectional and observational studies were included. Data on bruxism prevalence and associated factors were extracted, and a meta\u2010analysis was performed using both fixed\u2010effects (FE) and random\u2010effects (RE) models of MedCalc software. Heterogeneity among studies was assessed using\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistics. New Castle\u2010Ottawa Scale was used to evaluate methodological quality of the included studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight studies met the pre\u2010defined inclusion criteria and were included in the analysis. Seven studies used a questionnaire to assess bruxism. The pooled proportion estimate for occurrence of DS across the included studies was found to be 0.33 (95% CI: 0.22\u20130.45) as per the RE model and 0.35 (95% CI: 0.31\u20130.450) as per FE model in the quantitative analysis. All studies exhibited good methodological quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis provide evidence of a significant prevalence of bruxism among individuals with DS. The findings highlight the association of bruxism with other oral health issues and specific chromosomal abnormalities. Comprehensive oral health assessments, including diagnostic procedures like Polysomnography, are essential for addressing the unique oral health needs of individuals with DS. Further studies are recommended with a valid tool for the diagnosis. Early interventions and management strategies need to be tailored to this population, considering the multifaceted nature of oral health concerns in individuals with DS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13563","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T20:58:45Z","timestamp":1690577925000},"page":"1498-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of bruxism in down syndrome patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Mohammad Khursheed","family":"Alam","sequence":"first","affiliation":[{"name":"Preventive Dentistry Department, College of Dentistry Jouf University  Sakaka Saudi Arabia"},{"name":"Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences Saveetha Dental College and Hospitals  Chennai India"},{"name":"Department of Public Health, Faculty of Allied Health Sciences Daffodil International University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Hamoud L.","family":"Alsharari","sequence":"additional","affiliation":[{"name":"Preventive Dentistry Department, College of Dentistry Jouf University  Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher A. L.","family":"Shayeb","sequence":"additional","affiliation":[{"name":"Clinical Science Department Center of Medical and Bioallied Health Sciences Research, Ajman University  Ajman UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sittana","family":"Elfadil","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Prosthodontics, College of Dentistry Center of Medical and Bio\u2010Allied Health Sciences Research. 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