{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:44:37Z","timestamp":1788871477757,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Masticatory parameters, such as reduced number of teeth and posterior contacts, have been shown to be associated with reduced cognitive status. The underlying mechanisms that affect these associations, are however, not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study aims to investigate the association between masticatory dysfunction and cognition and explore the mediating effect of brain structure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, 45 older adults with subjective masticatory dysfunction (mean age 72.3\u2009\u00b1\u20094.0\u2009years) were included. Mini\u2010Mental State Examination score &lt;25, brain trauma, neurological disease, neurodegenerative disorders, depression or poor Swedish language skills were criteria for exclusion. Cognitive functions (executive function and episodic memory) and masticatory dysfunction defined by functional occluding status (FOS; the number of occluding units and number of remaining teeth) were analysed with partial correlation models. Structural magnetic resonance imaging was performed on 28 feasible participants. Multiple regression analyses were performed to evaluate the predictive value of brain structure and white matter hypointensities (WM\u2010hypo) on cognitive functions. A mediation analysis was applied to assess significant predictor\/s of the association between FOS and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both episodic memory and executive functions were positively correlated with FOS. WM\u2010hypo predicted cognitive status (executive function,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u2009.01). WM\u2010hypo mediated 66.6% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) of the association between FOS and executive functions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Associations between FOS and cognitive functions are reported, where FOS, a potential modifiable risk factor, was related to both episodic memory and executive functions. The mediating effect of WM\u2010hypo on the association between FOS and executive functions highlights the impact of the vascularisation of the brain on the link between mastication and cognition. The present study provides increased knowledge that bridges the gap between masticatory dysfunction and cognition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13584","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T01:07:17Z","timestamp":1694740037000},"page":"1422-1431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["White matter abnormalities mediate the association between masticatory dysfunction and cognition among older adults"],"prefix":"10.1111","volume":"50","author":[{"given":"Linn","family":"Hedberg","sequence":"first","affiliation":[{"name":"Folktandv\u00e5rden Eastmaninstitutet  Stockholm Sweden"},{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Academic Centre for Geriatric Dentistry  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-3524","authenticated-orcid":false,"given":"Abhishek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Academic Centre for Geriatric Dentistry  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Skott","sequence":"additional","affiliation":[{"name":"Folktandv\u00e5rden Eastmaninstitutet  Stockholm Sweden"},{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Academic Centre for Geriatric Dentistry  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Ivan","family":"Smedberg","sequence":"additional","affiliation":[{"name":"Folktandv\u00e5rden Eastmaninstitutet  Stockholm Sweden"},{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Seiger","sequence":"additional","affiliation":[{"name":"Academic Centre for Geriatric Dentistry  Stockholm Sweden"},{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS) Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Sandborgh\u2010Englund","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Academic Centre for Geriatric Dentistry  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Love Engstr\u00f6m","family":"Nordin","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS) Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Diagnostic Medical Physics Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingemar","family":"K\u00e5reholt","sequence":"additional","affiliation":[{"name":"Aging Research Center Karolinska Institutet and Stockholm University  Stockholm Sweden"},{"name":"School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Tzortzakakis","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Physics and Nuclear Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Westman","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS) Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Neuroimaging, Centre for Neuroimaging Sciences Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Trulsson","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Academic Centre for Geriatric Dentistry  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3926-8656","authenticated-orcid":false,"given":"Urban","family":"Ekman","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS) Karolinska Institutet  Stockholm Sweden"},{"name":"Women's Health and Allied Health Professionals Theme, Medical Unit, Medical Psychology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2021.05.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1927-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13231"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00225"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.05.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0729-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12763"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2021.05.011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.811335"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04154.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.110942"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103156"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2004.01.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2017.05.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.11.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.02.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079199"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3122"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132635.75819.E5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3666"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170573"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-104981"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0693-z"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa025"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12657"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12603"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00354"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01654-5"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12016"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13393"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00023-1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2020.08.003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/2380084418785863"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0b013e3182741948"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.8.2.145"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2011.609838"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2013.00049"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102662"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0081175012444861"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09431-9"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.032614"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118305"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3048-13.2013"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2007.01842.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12283"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00415"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158070"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200817"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0810743"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.03.003"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2022.06.005"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.6.929"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.3.418"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03490.x"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.11.013"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0814"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-020-00267-w"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.111189"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(96)00081-7"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2012.02316.x"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14036"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496730"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190741"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13508"},{"key":"e_1_2_10_70_1","first-page":"521","article-title":"Validation of the Eichner index in relation to occlusal force and masticatory performance","volume":"23","author":"Ikebe K","year":"2010","journal-title":"Int J Prosthodont"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/2380084416633102"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12380"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T06:31:50Z","timestamp":1701239510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.13584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":71,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/joor.13584"],"URL":"https:\/\/doi.org\/10.1111\/joor.13584","archive":["Portico"],"relation":{},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]},"assertion":[{"value":"2022-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}