{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T17:13:55Z","timestamp":1777137235345,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971247"],"award-info":[{"award-number":["31971247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371003"],"award-info":[{"award-number":["82371003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mandibular condylar hypoplasia negatively affects patient's facial appearance and dentofacial function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effect of local injection of the drug abaloparatide (ABL), an analogue of parathyroid hormone related protein (PTHrP), on promoting lengthening of the mandibular condyle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty adolescent male Sprague\u2013Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3\u2009days in the temporomandibular joint (TMJ) cavity. Cone\u2010beam computed tomography and immunohistochemistry assays were performed at 2, 4 and 6\u2009weeks since the injection. Mandibular condylar chondrocytes (MCC) and pre\u2010osteoblasts were treated with ABL or PBS, followed by the CCK\u20108 detection, IC50, real\u2010time PCR assay, Western Blot and immunofluorescence staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In vivo, compared with the control, the ABL group significantly increased the mandibular condylar process length (by 1.34\u2009\u00b1\u20090.59\u2009mm at 6\u2009weeks), the thickness of the cartilage layer, and enhanced the matrix synthesis. The ABL group had significant up\u2010regulation of SOX 9, COL II, PTHrP and PTH1R, down\u2010regulation of COL X in the cartilage, up\u2010regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone. In vitro, the intra\u2010TMJ injection of ABL promoted the MCC proliferation, with up\u2010regulated expression of chondrogenic genes, and enhanced osteogenic differentiation of the pre\u2010osteoblasts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intra\u2010TMJ injection of abaloparatide promotes mandibular condyle lengthening in the adolescent rats via enhancing chondrogenesis in the mandibular condylar cartilage and ossification in the subchondral bone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13597","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T02:20:32Z","timestamp":1695176432000},"page":"380-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Local injection of abaloparatide promotes mandibular condyle lengthening in adolescent rats via enhancing chondrogenesis and ossification"],"prefix":"10.1111","volume":"51","author":[{"given":"Lin","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Mei","sequence":"additional","affiliation":[{"name":"Discipline of Orthodontics, Department of Oral Sciences, Faculty of Dentistry University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hexu","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-7268","authenticated-orcid":false,"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"137","article-title":"Prevalence of skeletal components of malocclusion using composite cephalometric analysis","volume":"23","author":"Waheedul\u2010Hamid AS","year":"2003","journal-title":"Pak Oral Dent J"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.12.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04686-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.03.029"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4861924"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2319\/120417-829.1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.05.023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5580"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab005"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0662-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00068-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200811"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0780-7"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3930"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/tea.2007.0261"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007740050003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2319\/102606-441.1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/1305-7456.137624"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.04.012"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3870"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2319\/030914-170.1"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2009.0564"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2020.04.002"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.05.032"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1179\/146531204225020436"},{"issue":"1","key":"e_1_2_11_27_1","first-page":"79","article-title":"Effects of local administration of insulin\u2010like growth factor\u2010I on mandibular condylar growth in rats","volume":"50","author":"Itoh K","year":"2003","journal-title":"J Med Dent Sci"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.01.049"},{"issue":"5","key":"e_1_2_11_29_1","first-page":"624","article-title":"Anti\u2010senescence and anti\u2010inflammatory effects of the C\u2010terminal moiety of PTHrP peptides in OA osteoblasts","volume":"72","author":"Platas J","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4025"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.108.BJR-2020-0165.R2"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.910.BJR-2020-0018.R1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100223"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.03.015"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.04.016"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094321"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.1.160"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199808)251:4<439::AID-AR3>3.0.CO;2-N"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01779-08"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00218-6"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1171104"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808048200"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0422-4"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19052706"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjp060"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12171"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T01:43:32Z","timestamp":1705715012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.13597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/joor.13597"],"URL":"https:\/\/doi.org\/10.1111\/joor.13597","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.13597\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13597\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13597\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13597\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13597\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}