{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:33Z","timestamp":1787015553202,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The diagnosis of chronic primary pain (CPP), according to the recently released International Classification of Disease (ICD\u201011) criteria, refers to conditions with complex aetiologies. CPP is characterized by specific clinical features such as generalized sensory hypersensitivity and widespread pain, and is associated with functional disability and emotional distress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated clinical features of CPP in individuals with painful temporomandibular disorders (TMD) and comorbidities (fibromyalgia, migraine and\/or tension\u2010type headache).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study was conducted with a sample of 129 individuals. Painful TMD, fibromyalgia and primary headaches were evaluated based on well\u2010established international criteria. Generalized sensory hypersensitivity was assessed using psychophysical tests. Symptoms of anxiety and depression were assessed by the Generalized Anxiety Disorder\u20107 and Patient Health Questionnaire\u20109. The Central Sensitization Inventory was applied to assess central sensitization\u2010related symptoms and the Pittsburg Sleep Quality Index to evaluate the quality of sleep. The presence of widespread pain was assessed using a body map. The sample was stratified into three groups: control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925), TMD\u2014painful TMD only (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935) and TMD\u2009+\u2009Cm\u2014painful TMD and comorbidities (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969). Statistical analysis was performed using one\u2010way ANOVA, chi\u2010squared test and ANCOVA, considering gender as a covariate (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to controls, individuals presenting painful TMD and comorbidities showed lower pressure pain thresholds in all evaluated areas (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u2009.012) and a higher number of painful areas in the body (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001). They presented more symptoms of anxiety (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.040) and depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018), and a higher score in the Central Sensitization Inventory (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u2009.006) than the other groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individuals with painful TMD and comorbidities presented more clinical features of CPP compared to those affected by TMD only.<\/jats:p>\n                  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