{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:45:23Z","timestamp":1783608323045,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conditioned pain modulation (CPM) is a potential predictor of treatment response that has not been studied in temporomandibular disorders (TMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted a randomised, double\u2010blind, placebo\u2010controlled trial (RCT) of duloxetine in addition to self\u2010management (SM) strategies to investigate its efficacy to reduce pain intensity in painful TMD patients. Moreover, we investigated whether baseline CPM would predict the duloxetine efficacy to reduce TMD pain intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty participants were randomised to duloxetine 60\u2009mg or placebo for 12\u2009weeks. The primary outcomes were the change in the pain intensity from baseline to week\u201012 and CPM\u2010sequential paradigm at baseline. Safety, physical and emotional functioning outcomes were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 80 participants randomised, 78 were included in intention\u2010to\u2010treat analysis. Pain intensity decreased for SM\u2010duloxetine and SM\u2010placebo but did not differ between groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.82). A more efficient CPM was associated with a greater pain intensity reduction regardless of the treatment group (<jats:italic>p<\/jats:italic>\u2009=\u2009.035). Physical and emotional functioning did not differ between groups, but adverse events (<jats:italic>p<\/jats:italic>\u2009=\u2009.014), sleep impairment (<jats:italic>p<\/jats:italic>\u2009=\u2009.003) and catastrophizing symptoms (<jats:italic>p<\/jats:italic>\u2009=\u2009.001) were more prevalent in SM\u2010duloxetine group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study failed to provide evidence of a beneficial effect of adding duloxetine to SM strategies for treatment of painful TMD. Nonetheless, this RCT has shown the feasibility of applying pain modulation assessment to predict short\u2010term treatment response in painful TMD patients, which confirms previous finds that CPM evaluation may serve a step forward in individualising pain treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13628","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T23:48:51Z","timestamp":1700869731000},"page":"476-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prediction of duloxetine efficacy in addition to self\u2010management in painful temporomandibular disorders: A randomised, placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-8519","authenticated-orcid":false,"given":"Dyna Mara Ara\u00fajo Oliveira","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-3626","authenticated-orcid":false,"given":"Fl\u00e1via Fonseca Carvalho","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Ayla","family":"Raimundini","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-7678","authenticated-orcid":false,"given":"Leonardo Rigoldi","family":"Bonjardim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-5020","authenticated-orcid":false,"given":"Yuri Martins","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Piracicaba Dental School University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-4658","authenticated-orcid":false,"given":"Paulo C\u00e9sar Rodrigues","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.02.004"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32833c348b"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.10.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1124-6"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000739"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.554899"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.03.001"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1664510"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300209"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.075960"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001263"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","unstructured":"National Academies of Sciences E and Medicine; Health and Medicine Division; Board on Health Care Services; Board on Health Sciences Policy; Committee on Temporomandibular Disorders Temporomandibular Disorders: Priorities for Research and CareNational Academies Press (US).https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK555057\/doi:10.17226\/25652. 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