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In silico simulations, such as musculoskeletal modelling, can be used to predict post\u2010operative mandibular kinematics. It is important to validate the mandibular musculoskeletal model and analyse the factors influencing its accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the jaw opening\u2010closing movements after mandibular reconstruction, as predicted by the subject\u2010specific musculoskeletal model, and the factors influencing its accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten mandibular reconstruction patients were enrolled in this study. Cone\u2010beam computed tomography images, mandibular movements, and surface electromyogram signals were recorded preoperatively. A subject\u2010specific mandibular musculoskeletal model was established to predict surgical outcomes using patient\u2010averaged muscle parameter changes as model inputs. Jaw bone geometry was replaced by surgical planning results, and the muscle insertion sites were registered based on the non\u2010rigid iterative closest point method. The predicted jaw kinematic data were validated based on 6\u2010month post\u2010operative measurements. Correlations between the prediction accuracy and patient characteristics (age, pathology and surgical scope) were further analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The root mean square error (RMSE) for lower incisor displacement was 31.4%, and the error for peak magnitude of jaw opening was 4.9\u2009mm. Age, post\u2010operative infection and radiotherapy influenced the prediction accuracy. The amount of masseter detachment showed little correlation with jaw opening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The mandibular musculoskeletal model successfully predicted short\u2010range jaw opening functions after mandibular reconstruction. It provides a novel surgical planning method to predict the risk of developing trismus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13670","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T01:41:47Z","timestamp":1711590107000},"page":"1050-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prediction of jaw opening function after mandibular reconstruction using subject\u2010specific musculoskeletal modelling"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-7018","authenticated-orcid":false,"given":"Junpeng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory of Digital Stomatology  Beijing 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